Enables P-type sodium:potassium-exchanging transporter activity. Involved in action potential; monoatomic ion transport; and regulation of muscle contraction. Located in membrane. Expressed in several structures, including coelomocyte; intestine; neurons; pharynx; and vulval muscle. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2DD; alternating hemiplegia of childhood; and brain disease (multiple). Is an ortholog of human ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3).
Enables several functions, including ATP binding activity; ATP hydrolysis activity; and microtubule severing ATPase activity. Involved in several processes, including microtubule cytoskeleton organization; positive regulation of microtubule depolymerization; and vulval development. Located in microtubule cytoskeleton; perinuclear region of cytoplasm; and protein-containing complex. Expressed in several structures, including intestine; mechanosensory neurons; somatic nervous system; tail ganglion; and vulva. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Is an ortholog of human SPAST (spastin).