Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell fate specification; positive regulation of developmental process; and positive regulation of egg-laying behavior. Located in nucleus. Expressed in several structures, including E lineage cell; M.v nucleus; RMH; body wall muscle cell from M lineage; and neuroblasts. Human ortholog(s) of this gene implicated in several diseases, including Coffin-Siris syndrome (multiple); hypotrichosis-lymphedema-telangiectasia syndrome; and hypotrichosis-lymphedema-telangiectasia-renal defect syndrome. Is an ortholog of several human genes including SOX11 (SRY-box transcription factor 11); SOX18 (SRY-box transcription factor 18); and SOX4 (SRY-box transcription factor 4).
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in neuron fate specification. Predicted to be located in nucleus. Expressed in several structures, including AWC-ON; head neurons; hypodermis; neuroblasts; and rectal epithelial cell. Human ortholog(s) of this gene implicated in several diseases, including X-linked panhypopituitarism; carcinoma (multiple); and syndromic microphthalmia 3. Is an ortholog of human SOX2 (SRY-box transcription factor 2).
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in neuron differentiation. Predicted to be located in nucleus. Expressed in head neurons and rectal epithelial cell. Is an ortholog of human SOX14 (SRY-box transcription factor 14) and SOX21 (SRY-box transcription factor 21).
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell fate commitment; regulation of DNA-templated transcription; and vulval development. Located in nucleus. Expressed in several structures, including developing hermaphrodite gonad; egg-laying apparatus; intestinal cell; neurons; and uterine pi cell. Human ortholog(s) of this gene implicated in high grade glioma. Is an ortholog of human SOX13 (SRY-box transcription factor 13); SOX5 (SRY-box transcription factor 5); and SOX6 (SRY-box transcription factor 6).