sor-3

Caenorhabditis elegans

Predicted to enable chromatin binding activity and histone binding activity. Involved in several processes, including negative regulation of DNA-templated transcription; nematode larval development; and neuron differentiation. Located in cytoplasm and nucleus. Expressed widely.

mum-3

Caenorhabditis elegans

sop-2

Caenorhabditis elegans

Enables RNA binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of cytoplasmic mRNA processing body assembly; neuron differentiation; and regulation of gene expression. Located in nuclear speck. Expressed widely.

gla-3

Caenorhabditis elegans

Predicted to enable metal ion binding activity. Located in cell cortex. Expressed in germ line; muscle cell; and somatic cell.

dop-3

Caenorhabditis elegans

Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including adenylate cyclase-inhibiting dopamine receptor signaling pathway; male mating behavior; and response to odorant. Predicted to be located in plasma membrane. Expressed in neurons. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; alcohol dependence; drug dependence (multiple); and end stage renal disease. Is an ortholog of human DRD3 (dopamine receptor D3).

pag-3

Caenorhabditis elegans

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription corepressor activity; and transcription corepressor binding activity. Involved in several processes, including negative regulation of secretion by cell; neuroblast fate specification; and regulation of locomotion. Located in nucleus. Expressed in several structures, including P1.aap; P11.aaap; P12.aaap; neurons; and retrovesicular ganglion. Used to study alcohol use disorder. Is an ortholog of human ZNF683 (zinc finger protein 683).

cogc-3

Caenorhabditis elegans

Involved in gonad morphogenesis and regulation of cell migration. Located in Golgi apparatus and endoplasmic reticulum. Expressed in intestine; pharynx; seam cell; and vulva. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Is an ortholog of human COG3 (component of oligomeric golgi complex 3).