ulp-1

Caenorhabditis elegans

Predicted to enable deSUMOylase activity. Involved in several processes, including embryo development; positive regulation of error-prone translesion synthesis; and protein desumoylation. Predicted to be located in nucleus. Is an ortholog of human SENP2 (SUMO specific peptidase 2).

sop-2

Caenorhabditis elegans

Enables RNA binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of cytoplasmic mRNA processing body assembly; neuron differentiation; and regulation of gene expression. Located in nuclear speck. Expressed widely.

sop-3

Caenorhabditis elegans

Predicted to be located in nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P8.p hermaphrodite; and neurons.

K04C1.2

Caenorhabditis elegans

Enriched in several structures, including ABalaaaarl; ABalaaaarr; ABplpaaaap; PVR; and mechanosensory neurons based on microarray; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including cyc-1; nuo-6; and isp-1 based on microarray and RNA-seq studies. Is affected by four chemicals including Zidovudine; paraquat; and Chlorpyrifos based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domain: Sterile alpha motif/pointed domain superfamily.

sor-3

Caenorhabditis elegans

Predicted to enable chromatin binding activity and histone binding activity. Involved in several processes, including negative regulation of DNA-templated transcription; nematode larval development; and neuron differentiation. Located in cytoplasm and nucleus. Expressed widely.

zim-2

Caenorhabditis elegans

Predicted to be involved in meiotic chromosome segregation. Located in condensed nuclear chromosome.

dop-3

Caenorhabditis elegans

Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including adenylate cyclase-inhibiting dopamine receptor signaling pathway; male mating behavior; and response to odorant. Predicted to be located in plasma membrane. Expressed in neurons. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; alcohol dependence; drug dependence (multiple); and end stage renal disease. Is an ortholog of human DRD3 (dopamine receptor D3).

bro-1

Caenorhabditis elegans

Enables transcription corepressor activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; nematode male tail tip morphogenesis; and positive regulation of locomotion involved in locomotory behavior. Located in nucleus. Part of core-binding activity factor complex. Expressed in hypodermis; muscle cell; pharyngeal neurons; ray precursor cell; and uterine seam cell. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia and hepatocellular carcinoma. Is an ortholog of human CBFB (core-binding factor subunit beta).

mau-2

Caenorhabditis elegans

Predicted to enable double-stranded DNA binding activity. Involved in anterior/posterior axon guidance; dorsal/ventral axon guidance; and egg-laying behavior. Located in axon and cytoplasm. Expressed in nervous system; oocyte; and vulval muscle. Is an ortholog of human MAU2 (MAU2 sister chromatid cohesion factor).