Enables transcription cis-regulatory region binding activity. Involved in several processes, including gonad development; positive regulation of transcription by RNA polymerase II; and vulval development. Located in nucleus. Expressed in several structures, including tail. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; cerebral infarction; and syndromic microphthalmia 13. Is an ortholog of human HMGB3 (high mobility group box 3).
Predicted to enable RNA binding activity. Predicted to be involved in regulation of mRNA splicing, via spliceosome. Human ortholog(s) of this gene implicated in congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay. Is an ortholog of human SON (SON DNA and RNA binding protein).
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; female gamete generation; and positive regulation of vulval development. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 4; Noonan syndrome 9; and reproductive organ cancer (multiple). Is an ortholog of human SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1).