Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including epidermis morphogenesis; positive regulation of transcription by RNA polymerase II; and sensory perception of touch. Located in nucleus. Expressed in several structures, including anterior hypodermis; neurons; pseudocoelom; socket cell; and somatic nervous system. Used to study non-syndromic X-linked intellectual disability 1. Human ortholog(s) of this gene implicated in several diseases, including X-linked lissencephaly 2; X-linked recessive disease (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human ALX4 (ALX homeobox 4) and ARX (aristaless related homeobox).