smp-1

Caenorhabditis elegans

Enables semaphorin receptor binding activity. Involved in nematode male tail mating organ morphogenesis. Predicted to be located in plasma membrane. Expressed in several structures, including hermaphrodite distal tip cell; non-striated muscle; ray; somatic nervous system; and vulval cell. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 16 with or without anosmia; progressive myoclonus epilepsy; and rheumatoid arthritis. Is an ortholog of several human genes including SEMA3B (semaphorin 3B); SEMA3C (semaphorin 3C); and SEMA6C (semaphorin 6C).

plx-1

Caenorhabditis elegans

Enables semaphorin receptor activity. Involved in epidermis development; nematode male tail mating organ morphogenesis; and nematode male tail tip morphogenesis. Located in ruffle membrane. Expressed in several structures, including DA9; epithelial cell; non-striated muscle; somatic nervous system; and tail. Is an ortholog of several human genes including PLXNA1 (plexin A1); PLXNA2 (plexin A2); and PLXNA3 (plexin A3).

vab-23

Caenorhabditis elegans

Involved in several processes, including embryonic body morphogenesis; epidermis morphogenesis; and vulval development. Located in nuclear speck. Expressed in several structures, including hermaphrodite somatic gonadal cell; ventral uterine precursor; vulval cell; vulval muscle; and vulval precursor cell. Human ortholog(s) of this gene implicated in Miles-Carpenter syndrome. Is an ortholog of human ZC4H2 (zinc finger C4H2-type containing).

poml-3

Caenorhabditis elegans

Enriched in ABplapaaaa; ABprapaaaa; hyp12; hypodermis; and intestine based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including nuo-6; numr-2; and numr-1 based on microarray; RNA-seq; and proteomic studies. Is affected by twenty-one chemicals including manganese chloride; D-glucose; and 4-bromodiphenyl ether based on RNA-seq and microarray studies. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); autoimmune disease (multiple); and eye disease (multiple). Is predicted to encode a protein with the following domains: Six-bladed beta-propeller, TolB-like; SMP-30/Gluconolactonase/LRE-like region; and Serum paraoxonase/arylesterase. Is an ortholog of human PON1 (paraoxonase 1); PON2 (paraoxonase 2); and PON3 (paraoxonase 3). Human PON1 enables several functions, including aryldialkylphosphatase activity; arylesterase activity; and protein homodimerization activity.

dgn-2

Caenorhabditis elegans

Predicted to enable laminin binding activity. Predicted to be involved in axon guidance; morphogenesis of an epithelium; and nerve development. Predicted to be located in sarcolemma. Predicted to be part of dystroglycan complex. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; Fukuyama congenital muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2D; autosomal recessive limb-girdle muscular dystrophy type 2P; bronchopulmonary dysplasia; congenital muscular dystrophy-dystroglycanopathy type A9; and inclusion body myositis. Is an ortholog of human DAG1 (dystroglycan 1).

dgn-1

Caenorhabditis elegans

Predicted to enable laminin binding activity. Involved in anatomical structure morphogenesis; inductive cell migration; and positive regulation of locomotion. Located in basal plasma membrane. Expressed in several structures, including ALM; PVP; e2; gonad; and lumbar ganglion. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; Fukuyama congenital muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2D; autosomal recessive limb-girdle muscular dystrophy type 2P; bronchopulmonary dysplasia; congenital muscular dystrophy-dystroglycanopathy type A9; and inclusion body myositis. Is an ortholog of human DAG1 (dystroglycan 1).