sex-2

Caenorhabditis elegans

Acts upstream of or within primary sex determination and transcription by RNA polymerase II.

unc-100

Caenorhabditis elegans

cod-11

Caenorhabditis elegans

sex-1

Caenorhabditis elegans

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in primary sex determination and regulation of gene expression. Located in nucleus. Expressed in gonad; intestine; oocyte; and ventral uterine precursor. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); liver disease (multiple); and lung carcinoma (multiple). Is an ortholog of human NR1D1 (nuclear receptor subfamily 1 group D member 1) and NR1D2 (nuclear receptor subfamily 1 group D member 2).

let-100

Caenorhabditis elegans

sea-1

Caenorhabditis elegans

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in dosage compensation by hypoactivation of X chromosome; positive regulation of transcription by RNA polymerase II; and sex determination. Located in nucleus. Expressed in several structures, including coelomocyte; head muscle; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in Abruzzo-Erickson syndrome; X-linked cleft palate with or without ankyloglossia; and bone disease (multiple). Is an ortholog of several human genes including TBX15 (T-box transcription factor 15); TBX4 (T-box transcription factor 4); and TBX6 (T-box transcription factor 6).

ceh-100

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in brain development; neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed widely.

sdc-1

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in dosage compensation by hypoactivation of X chromosome; negative regulation of transcription by RNA polymerase II; and sex determination. Located in nuclear chromosome.

lin-27

Caenorhabditis elegans

tra-4

Caenorhabditis elegans

Enables histone deacetylase binding activity. Involved in hermaphrodite somatic sex determination; negative regulation of vulval development; and regulation of gene expression. Located in nucleus. Expressed in several structures, including excretory cell and ventral nerve cord.