sem-5

Caenorhabditis elegans

Enables epidermal growth factor receptor binding activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; male genitalia development; and regulation of vulval development. Predicted to be located in cytoplasm; nucleoplasm; and plasma membrane. Predicted to be part of COP9 signalosome. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P7.p hermaphrodite; and P8.p hermaphrodite. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 114; breast cancer; and reproductive organ cancer (multiple). Is an ortholog of human GRB2 (growth factor receptor bound protein 2).

him-5

Caenorhabditis elegans

Involved in meiotic DNA double-strand break formation involved in reciprocal meiotic recombination and meiotic chromosome segregation. Located in condensed chromosome. Expressed in gonad.

let-5

Caenorhabditis elegans

Acts upstream of or within nematode larval development.

such-5

Caenorhabditis elegans

Y67A10A.7

Caenorhabditis elegans

Predicted to be located in mitochondrion. Is an ortholog of several human genes including ARMCX1 (armadillo repeat containing X-linked 1); ARMCX2 (armadillo repeat containing X-linked 2); and ARMCX3 (armadillo repeat containing X-linked 3).

him-7

Caenorhabditis elegans

sem-4

Caenorhabditis elegans

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cell differentiation; regulation of gene expression; and response to oxidative stress. Located in nucleus. Expressed in several structures, including HSN; M lineage cell; rectal epithelial cell; rectum; and tail hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Duane retraction syndrome; Duane-radial ray syndrome; and Holt-Oram syndrome. Is an ortholog of human SALL1 (spalt like transcription factor 1) and SALL3 (spalt like transcription factor 3).

him-2

Caenorhabditis elegans

bbs-5

Caenorhabditis elegans

Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in cilium assembly and intracellular transport. Located in cilium. Expressed in head; neurons; outer labial neurons; and tail. Used to study Bardet-Biedl syndrome and ciliopathy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 5. Is an ortholog of human BBS5 (Bardet-Biedl syndrome 5).

F38E9.1

Caenorhabditis elegans

Predicted to enable phosphoric diester hydrolase activity. Predicted to be involved in lipid metabolic process. Is an ortholog of human PLCXD2 (phosphatidylinositol specific phospholipase C X domain containing 2) and PLCXD3 (phosphatidylinositol specific phospholipase C X domain containing 3).