osm-11

Caenorhabditis elegans

Enables Notch binding activity. Involved in several processes, including positive regulation of Notch signaling pathway; response to osmotic stress; and vulval development. Located in apical part of cell and extracellular space. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P8.p hermaphrodite; and hermaphrodite gonad.

mdt-29

Caenorhabditis elegans

Involved in lateral inhibition; positive regulation of Notch signaling pathway; and regulation of cell fate specification. Predicted to be located in nucleus. Predicted to be part of mediator complex. Expressed in body wall musculature.

sel-12

Caenorhabditis elegans

Predicted to enable endopeptidase activity. Involved in several processes, including apical protein localization; egg-laying behavior; and regulation of signal transduction. Located in perinuclear region of cytoplasm. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 3; Alzheimer's disease 4; Pick's disease; dilated cardiomyopathy (multiple); and hidradenitis suppurativa. Is an ortholog of human PSEN1 (presenilin 1) and PSEN2 (presenilin 2).

sel-11

Caenorhabditis elegans

Predicted to enable ubiquitin protein ligase activity. Involved in regulation of Notch signaling pathway and regulation of gene expression. Predicted to be located in endoplasmic reticulum quality control compartment. Expressed in body wall musculature; hypodermis; and pharynx. Is an ortholog of human SYVN1 (synoviolin 1).

sel-10

Caenorhabditis elegans

Enables protein homodimerization activity and protein kinase binding activity. Involved in several processes, including negative regulation of Notch signaling pathway; negative regulation of centrosome duplication; and regulation of vulval development. Located in axon and cytoplasm. Expressed in body wall musculature; gonad; intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in developmental delay, hypotonia, and impaired language. Is an ortholog of human FBXW7 (F-box and WD repeat domain containing 7).

hop-1

Caenorhabditis elegans

Predicted to enable endopeptidase activity. Involved in Notch signaling pathway and positive regulation of germ cell proliferation. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be part of gamma-secretase complex.

sel-7

Caenorhabditis elegans

Enables identical protein binding activity and sequence-specific DNA binding activity. Involved in several processes, including lateral inhibition; negative regulation of transcription by RNA polymerase II; and positive regulation of Notch signaling pathway. Located in nucleus. Expressed in body wall musculature; pharyngeal muscle cell; and seam cell.

sel-4

Caenorhabditis elegans

fer-14

Caenorhabditis elegans

spe-14

Caenorhabditis elegans