sec-61.A

Caenorhabditis elegans

Predicted to enable protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation and post-translational protein targeting to membrane, translocation. Predicted to be located in membrane. Predicted to be part of Sec61 translocon complex. Human ortholog(s) of this gene implicated in common variable immunodeficiency; familial juvenile hyperuricemic nephropathy; and severe congenital neutropenia. Is an ortholog of human SEC61A1 (SEC61 translocon subunit alpha 1) and SEC61A2 (SEC61 translocon subunit alpha 2).

sec-61.B

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation and post-translational protein targeting to membrane, translocation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of Sec61 translocon complex. Is an ortholog of human SEC61B (SEC61 translocon subunit beta).

sec-61.G

Caenorhabditis elegans

Predicted to enable protein-transporting ATPase activity. Involved in oocyte growth and ovulation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of Sec61 translocon complex and Ssh1 translocon complex. Expressed in germ line. Is an ortholog of human SEC61G (SEC61 translocon subunit gamma).

mir-61

Caenorhabditis elegans

Involved in miRNA-mediated post-transcriptional gene silencing and regulation of vulval development. Expressed in several structures, including P5.p hermaphrodite; P5.pa; P5.pp; P7.p hermaphrodite; and P7.pa.

sec-16A.1

Caenorhabditis elegans

Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and protein localization to endoplasmic reticulum exit site. Located in endoplasmic reticulum exit site. Is an ortholog of human SEC16A (SEC16 homolog A, endoplasmic reticulum export factor).

lin-61

Caenorhabditis elegans

Predicted to enable chromatin binding activity and methylated histone binding activity. Involved in vulval development. Located in nucleus. Part of chromatin. Expressed widely. Is an ortholog of human L3MBTL2 (L3MBTL histone methyl-lysine binding protein 2) and MBTD1 (mbt domain containing 1).

sec-23

Caenorhabditis elegans

Predicted to enable GTPase activator activity. Predicted to be involved in COPII-coated vesicle cargo loading. Located in endoplasmic reticulum exit site. Expressed in hypodermis. Human ortholog(s) of this gene implicated in Cowden syndrome 7; congenital dyserythropoietic anemia type II; and craniolenticulosutural dysplasia. Is an ortholog of human SEC23B (SEC23 homolog B, COPII coat complex component).

scbp-2

Caenorhabditis elegans

Predicted to be located in ribosome.

cdap-2

Caenorhabditis elegans

Predicted to be involved in actin filament organization and cell migration. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 3 and immunodeficiency 61. Is an ortholog of human CD2AP (CD2 associated protein).

sec-24.1

Caenorhabditis elegans

Predicted to enable SNARE binding activity and zinc ion binding activity. Predicted to be involved in COPII-coated vesicle cargo loading. Predicted to be located in endoplasmic reticulum exit site. Predicted to be part of COPII vesicle coat. Expressed widely. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Is an ortholog of human SEC24D (SEC24 homolog D, COPII coat complex component).