sec-16A.1

Caenorhabditis elegans

Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and protein localization to endoplasmic reticulum exit site. Located in endoplasmic reticulum exit site. Is an ortholog of human SEC16A (SEC16 homolog A, endoplasmic reticulum export factor).

sec-23

Caenorhabditis elegans

Predicted to enable GTPase activator activity. Predicted to be involved in COPII-coated vesicle cargo loading. Located in endoplasmic reticulum exit site. Expressed in hypodermis. Human ortholog(s) of this gene implicated in Cowden syndrome 7; congenital dyserythropoietic anemia type II; and craniolenticulosutural dysplasia. Is an ortholog of human SEC23B (SEC23 homolog B, COPII coat complex component).

scbp-2

Caenorhabditis elegans

Predicted to be located in ribosome.

sec-24.1

Caenorhabditis elegans

Predicted to enable SNARE binding activity and zinc ion binding activity. Predicted to be involved in COPII-coated vesicle cargo loading. Predicted to be located in endoplasmic reticulum exit site. Predicted to be part of COPII vesicle coat. Expressed widely. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Is an ortholog of human SEC24D (SEC24 homolog D, COPII coat complex component).

sec-8

Caenorhabditis elegans

Predicted to be involved in Golgi to plasma membrane transport; chemical synaptic transmission; and exocytosis. Predicted to be located in growth cone membrane and synapse. Predicted to be part of exocyst. Expressed in embryonic cell; excretory canal; and hypodermis. Is an ortholog of human EXOC4 (exocyst complex component 4).

efsc-1

Caenorhabditis elegans

Predicted to enable translation elongation factor activity. Involved in selenocysteine incorporation. Is an ortholog of human EEFSEC (eukaryotic elongation factor, selenocysteine-tRNA specific).

tfg-1

Caenorhabditis elegans

Predicted to enable identical protein binding activity. Involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; protein localization; and regulation of cell size. Located in endoplasmic reticulum exit site and mitochondrion. Expressed in germ line; hypodermis; intestine; and muscle cell. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 57. Is an ortholog of human TFG (trafficking from ER to golgi regulator).

sec-5

Caenorhabditis elegans

Predicted to be involved in Golgi to plasma membrane transport and exocytosis. Predicted to be part of exocyst. Expressed in anchor cell; embryonic cell; and excretory canal. Is an ortholog of human EXOC2 (exocyst complex component 2).

trxr-1

Caenorhabditis elegans

Predicted to enable thioredoxin-disulfide reductase (NADPH) activity. Involved in ecdysis, collagen and cuticulin-based cuticle. Predicted to be located in cytosol and mitochondrion. Expressed in several structures, including hypodermis; interfacial epithelial cell; intestine; pharynx; and vulva. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; colorectal adenoma; and colorectal carcinoma. Is an ortholog of human TXNRD3 (thioredoxin reductase 3).