sec-16A.1

Caenorhabditis elegans

Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and protein localization to endoplasmic reticulum exit site. Located in endoplasmic reticulum exit site. Is an ortholog of human SEC16A (SEC16 homolog A, endoplasmic reticulum export factor).

sec-16A.2

Caenorhabditis elegans

Predicted to be involved in Golgi organization and protein localization to endoplasmic reticulum exit site. Predicted to be located in ER to Golgi transport vesicle membrane and endoplasmic reticulum exit site. Is an ortholog of human SEC16A (SEC16 homolog A, endoplasmic reticulum export factor).

gfi-2

Caenorhabditis elegans

Predicted to enable enzyme inhibitor activity and myosin phosphatase regulator activity. Predicted to be located in cytoplasm. Is an ortholog of human PPP1R16A (protein phosphatase 1 regulatory subunit 16A) and PPP1R16B (protein phosphatase 1 regulatory subunit 16B).

F37A4.1

Caenorhabditis elegans

Predicted to enable acylglycerol lipase activity and phospholipase activity. Predicted to be involved in monoacylglycerol catabolic process and phosphatidylserine catabolic process. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 86. Is an ortholog of human ABHD16A (abhydrolase domain containing 16A, phospholipase).

sec-23

Caenorhabditis elegans

Predicted to enable GTPase activator activity. Predicted to be involved in COPII-coated vesicle cargo loading. Located in endoplasmic reticulum exit site. Expressed in hypodermis. Human ortholog(s) of this gene implicated in Cowden syndrome 7; congenital dyserythropoietic anemia type II; and craniolenticulosutural dysplasia. Is an ortholog of human SEC23B (SEC23 homolog B, COPII coat complex component).

scbp-2

Caenorhabditis elegans

Predicted to be located in ribosome.

sec-24.1

Caenorhabditis elegans

Predicted to enable SNARE binding activity and zinc ion binding activity. Predicted to be involved in COPII-coated vesicle cargo loading. Predicted to be located in endoplasmic reticulum exit site. Predicted to be part of COPII vesicle coat. Expressed widely. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Is an ortholog of human SEC24D (SEC24 homolog D, COPII coat complex component).

sec-8

Caenorhabditis elegans

Predicted to be involved in Golgi to plasma membrane transport; chemical synaptic transmission; and exocytosis. Predicted to be located in growth cone membrane and synapse. Predicted to be part of exocyst. Expressed in embryonic cell; excretory canal; and hypodermis. Is an ortholog of human EXOC4 (exocyst complex component 4).

efsc-1

Caenorhabditis elegans

Predicted to enable translation elongation factor activity. Involved in selenocysteine incorporation. Is an ortholog of human EEFSEC (eukaryotic elongation factor, selenocysteine-tRNA specific).

gop-1

Caenorhabditis elegans

Predicted to be involved in endosomal transport; endosome to lysosome transport; and regulation of autophagosome maturation. Predicted to be located in endolysosome membrane and late endosome. Expressed in coelomocyte; intestinal cell; non-striated muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in Addison's disease and autoimmune disease (multiple). Is an ortholog of human CLEC16A (C-type lectin domain containing 16A).