Predicted to enable ribonucleoprotein complex binding activity. Involved in triglyceride metabolic process. Located in nuclear body. Expressed in gonad. Used to study Renpenning syndrome. Human ortholog(s) of this gene implicated in Renpenning syndrome. Is an ortholog of human PQBP1 (polyglutamine binding protein 1).
Predicted to enable ATP:ADP antiporter activity. Involved in determination of adult lifespan; mitochondrion organization; and positive regulation of apoptotic process. Located in mitochondrion. Expressed in several structures, including body wall musculature; hermaphrodite somatic gonadal cell; intestine; pharynx; and vulva. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2; facioscapulohumeral muscular dystrophy; intrinsic cardiomyopathy (multiple); and mitochondrial DNA depletion syndrome (multiple). Is an ortholog of human SLC25A4 (solute carrier family 25 member 4); SLC25A5 (solute carrier family 25 member 5); and SLC25A6 (solute carrier family 25 member 6).
Predicted to enable glyoxalase III activity. Involved in several processes, including cellular aldehyde metabolic process; cellular response to aldehyde; and monocarboxylic acid biosynthetic process. Located in cytoplasm and nucleus. Expressed in intestine. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease 7; Parkinsonism; and middle cerebral artery infarction. Is an ortholog of human PARK7 (Parkinsonism associated deglycase).
Predicted to enable myo-inositol:proton symporter activity. Predicted to be involved in myo-inositol transport and transmembrane transport. Located in apical plasma membrane. Expressed in intestinal cell. Is an ortholog of human SLC2A13 (solute carrier family 2 member 13).
Predicted to enable enoyl-CoA hydratase activity and long-chain-3-hydroxyacyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial fatty acid beta-oxidation multienzyme complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; mitochondrial trifunctional protein deficiency; and steatotic liver disease. Is an ortholog of human HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha).
Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity. Predicted to be involved in positive regulation of DNA-templated transcription, elongation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of cyclin/CDK positive transcription elongation factor complex. Expressed widely. Is an ortholog of human CCNT1 (cyclin T1).