sdc-3

Caenorhabditis elegans

Enables sequence-specific DNA binding activity. Involved in mitotic sister chromatid segregation; negative regulation of transcription by RNA polymerase II; and sex determination. Located in X chromosome and nucleus. Expressed in germ line and oocyte.

dpy-26

Caenorhabditis elegans

Involved in dosage compensation by hypoactivation of X chromosome; meiotic sister chromatid segregation; and mitotic sister chromatid segregation. Located in condensed nuclear chromosome. Part of dosage compensation complex. Expressed widely.

trpp-11

Caenorhabditis elegans

Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2S. Is an ortholog of human TRAPPC11 (trafficking protein particle complex subunit 11).

cisd-3.2

Caenorhabditis elegans

Predicted to enable 2 iron, 2 sulfur cluster binding activity. Predicted to be involved in protein maturation by [2Fe-2S] cluster transfer. Predicted to be located in mitochondrion. Is an ortholog of human CISD3 (CDGSH iron sulfur domain 3).

cisd-3.1

Caenorhabditis elegans

Predicted to enable 2 iron, 2 sulfur cluster binding activity. Predicted to be involved in protein maturation by [2Fe-2S] cluster transfer. Predicted to be located in mitochondrion. Is an ortholog of human CISD3 (CDGSH iron sulfur domain 3).

dpy-21

Caenorhabditis elegans

Enables histone H4K20 demethylase activity. Predicted to be involved in chromatin remodeling. Located in X chromosome. Is an ortholog of human RSBN1L (round spermatid basic protein 1 like).

sdc-2

Caenorhabditis elegans

Involved in dosage compensation by hypoactivation of X chromosome and negative regulation of transcription by RNA polymerase II. Located in nuclear chromosome.

dnj-15

Caenorhabditis elegans

Predicted to enable ATPase activator activity and protein-folding chaperone binding activity. Predicted to be involved in [2Fe-2S] cluster assembly. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in sideroblastic anemia. Is an ortholog of human HSCB (HscB mitochondrial iron-sulfur cluster cochaperone).

Y106G6D.5

Caenorhabditis elegans

Predicted to enable RNA binding activity and transcription termination site sequence-specific DNA binding activity. Predicted to be involved in termination of RNA polymerase II transcription. Predicted to be located in nuclear body. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2S and autosomal recessive distal hereditary motor neuronopathy 1. Is an ortholog of human IGHMBP2 (immunoglobulin mu DNA binding protein 2).

sdc-1

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in dosage compensation by hypoactivation of X chromosome; negative regulation of transcription by RNA polymerase II; and sex determination. Located in nuclear chromosome.