sdc-3

Caenorhabditis elegans

Enables sequence-specific DNA binding activity. Involved in mitotic sister chromatid segregation; negative regulation of transcription by RNA polymerase II; and sex determination. Located in X chromosome and nucleus. Expressed in germ line and oocyte.

dpy-21

Caenorhabditis elegans

Enables histone H4K20 demethylase activity. Predicted to be involved in chromatin remodeling. Located in X chromosome. Is an ortholog of human RSBN1L (round spermatid basic protein 1 like).

her-1

Caenorhabditis elegans

Enables signaling receptor binding activity. Involved in male sex determination. Located in extracellular region.

dpy-26

Caenorhabditis elegans

Involved in dosage compensation by hypoactivation of X chromosome; meiotic sister chromatid segregation; and mitotic sister chromatid segregation. Located in condensed nuclear chromosome. Part of dosage compensation complex. Expressed widely.

sdc-2

Caenorhabditis elegans

Involved in dosage compensation by hypoactivation of X chromosome and negative regulation of transcription by RNA polymerase II. Located in nuclear chromosome.

xol-1

Caenorhabditis elegans

Involved in dosage compensation by hypoactivation of X chromosome; intergenic mRNA trans splicing; and male sex determination. Predicted to be located in nucleus.

sdc-1

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in dosage compensation by hypoactivation of X chromosome; negative regulation of transcription by RNA polymerase II; and sex determination. Located in nuclear chromosome.

sws-1

Caenorhabditis elegans

Predicted to be involved in double-strand break repair via homologous recombination. Predicted to be part of Shu complex. Human ortholog(s) of this gene implicated in 46 XX gonadal dysgenesis and spermatogenic failure. Is an ortholog of human ZSWIM7 (zinc finger SWIM-type containing 7).

sex-2

Caenorhabditis elegans

Acts upstream of or within primary sex determination and transcription by RNA polymerase II.

dpy-28

Caenorhabditis elegans

Predicted to enable histone binding activity. Involved in meiotic sister chromatid segregation; mitotic sister chromatid segregation; and negative regulation of reciprocal meiotic recombination. Located in X chromosome and nucleus. Part of dosage compensation complex. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Is an ortholog of human NCAPD2 (non-SMC condensin I complex subunit D2).