sax-2

Caenorhabditis elegans

Involved in neuron projection development. Predicted to be located in cell cortex and site of polarized growth. Expressed in head neurons; tail neurons; and ventral nerve cord. Is an ortholog of human FRY (FRY microtubule binding protein) and FRYL (FRY like transcription coactivator).

sax-7

Caenorhabditis elegans

Enables ankyrin binding activity. Involved in several processes, including cell development; establishment of mitotic spindle orientation; and regulation of cell morphogenesis. Located in several cellular components, including axolemma; lateral plasma membrane; and somatodendritic compartment. Expressed in several structures, including gonad; neurons; pharynx; somatic nervous system; and vulval cell. Used to study MASA syndrome. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human NFASC (neurofascin) and NRCAM (neuronal cell adhesion molecule).

ZK512.4

Caenorhabditis elegans

Predicted to enable 7S RNA binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane. Predicted to be located in cytoplasm. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Expressed widely. Is an ortholog of human SRP9 (signal recognition particle 9).

F37F2.2

Caenorhabditis elegans

Predicted to enable 7S RNA binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Predicted to be located in cytoplasm and nucleolus. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Is an ortholog of human SRP19 (signal recognition particle 19).

F25G6.8

Caenorhabditis elegans

Predicted to enable 7S RNA binding activity and endoplasmic reticulum signal peptide binding activity. Predicted to be involved in protein targeting to ER. Predicted to be located in cytoplasm. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Is an ortholog of human SRP14 (signal recognition particle 14).

srpa-72

Caenorhabditis elegans

Predicted to enable 7S RNA binding activity. Predicted to contribute to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane. Predicted to be located in endoplasmic reticulum. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Is an ortholog of human SRP72 (signal recognition particle 72).

F21D5.7

Caenorhabditis elegans

Predicted to enable 7S RNA binding activity and endoplasmic reticulum signal peptide binding activity. Predicted to contribute to GTPase activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation. Predicted to be located in cytosol. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Human ortholog(s) of this gene implicated in severe congenital neutropenia 8. Is an ortholog of human SRP54 (signal recognition particle 54).

sax-3

Caenorhabditis elegans

Enables axon guidance receptor activity. Involved in generation of neurons and regulation of sensory neuron axon guidance. Located in plasma membrane. Expressed in several structures, including QR.a; QR.p; body wall musculature; neuroblasts; and neurons. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive congenital nystagmus; hematologic cancer (multiple); and myositis (multiple). Is an ortholog of human ROBO1 (roundabout guidance receptor 1); ROBO2 (roundabout guidance receptor 2); and ROBO3 (roundabout guidance receptor 3).

stn-2

Caenorhabditis elegans

Enables cell adhesion molecule binding activity. Located in several cellular components, including cell body; neuron projection; and sarcomere. Expressed in body wall musculature; enteric muscle; neurons; and vulva. Used to study Duchenne muscular dystrophy. Is an ortholog of human SNTG1 (syntrophin gamma 1).

ebax-1

Caenorhabditis elegans

Enables Hsp90 protein binding activity; misfolded protein binding activity; and signaling receptor binding activity. Involved in positive regulation of miRNA catabolic process; regulation of locomotion; and regulation of reproductive process. Located in axon; cytosol; and neuronal cell body. Part of Cul2-RING ubiquitin ligase complex. Expressed in excretory cell; nervous system; and vulval muscle. Is an ortholog of human ZSWIM8 (zinc finger SWIM-type containing 8).