rbx-2

Caenorhabditis elegans

Predicted to enable cullin family protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be part of Cul5-RING ubiquitin ligase complex. Is an ortholog of human RNF7 (ring finger protein 7).

rpac-40

Caenorhabditis elegans

Predicted to enable DNA-directed 5'-3' RNA polymerase activity and protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase I and transcription by RNA polymerase III. Predicted to be part of RNA polymerase I complex and RNA polymerase III complex. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 3 and hypomyelinating leukodystrophy 11. Is an ortholog of human POLR1C (RNA polymerase I and III subunit C).

nuaf-3

Caenorhabditis elegans

Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 18. Is an ortholog of human NDUFAF3 (NADH:ubiquinone oxidoreductase complex assembly factor 3).

rpoa-12

Caenorhabditis elegans

Predicted to enable DNA-directed 5'-3' RNA polymerase activity; nucleic acid binding activity; and zinc ion binding activity. Predicted to contribute to RNA polymerase I activity. Predicted to be involved in termination of RNA polymerase I transcription. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex. Is an ortholog of human POLR1H (RNA polymerase I subunit H).

rpoa-1

Caenorhabditis elegans

Predicted to enable DNA binding activity and DNA-directed 5'-3' RNA polymerase activity. Predicted to contribute to RNA polymerase I activity. Predicted to be involved in transcription by RNA polymerase I. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex. Human ortholog(s) of this gene implicated in acrofacial dysostosis Cincinnati type and hypomyelinating leukodystrophy. Is an ortholog of human POLR1A (RNA polymerase I subunit A).

nduo-3

Caenorhabditis elegans

Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in proton transmembrane transport. Predicted to be located in mitochondrial membrane. Predicted to be part of respiratory chain complex I.

ndub-8

Caenorhabditis elegans

Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and nuclear type mitochondrial complex I deficiency 32. Is an ortholog of human NDUFB8 (NADH:ubiquinone oxidoreductase subunit B8).

rpoa-2

Caenorhabditis elegans

Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and ribonucleoside binding activity. Predicted to contribute to RNA polymerase I activity. Predicted to be involved in transcription by RNA polymerase I. Located in nucleolus. Expressed in several structures, including intestine. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 4. Is an ortholog of human POLR1B (RNA polymerase I subunit B).

ndub-11

Caenorhabditis elegans

Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 3 and nuclear type mitochondrial complex I deficiency 30. Is an ortholog of human NDUFB11 (NADH:ubiquinone oxidoreductase subunit B11).

vps-15

Caenorhabditis elegans

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in autophagy and vacuolar transport. Predicted to be located in late endosome and nucleus-vacuole junction. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Is an ortholog of human PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4).