rme-8

Caenorhabditis elegans

Enables identical protein binding activity. Involved in several processes, including mechanosensory behavior; positive regulation of nematode male tail tip morphogenesis; and vesicle-mediated transport. Located in endosome. Expressed in coelomocyte; hypodermal cell; muscle cell; oocyte; and uterus. Human ortholog(s) of this gene implicated in Parkinson's disease. Is an ortholog of human DNAJC13 (DnaJ heat shock protein family (Hsp40) member C13).

rme-6

Caenorhabditis elegans

Enables small GTPase binding activity. Involved in endocytosis; molting cycle; and regulation of clathrin-dependent endocytosis. Located in clathrin-coated endocytic vesicle; early endosome; and plasma membrane. Expressed in several structures, including anterior gonad arm; coelomocyte; intestine; oocyte; and pharynx. Is an ortholog of human GAPVD1 (GTPase activating protein and VPS9 domains 1).

rme-1

Caenorhabditis elegans

Enables ATP hydrolysis activity and protein domain specific binding activity. Involved in several processes, including endocytic recycling; lipid tube assembly involved in organelle fission; and necroptotic process. Located in recycling endosome membrane. Expressed in coelomocyte; germ line; gonad; intestine; and pharynx. Is an ortholog of human EHD1 (EH domain containing 1).

rme-2

Caenorhabditis elegans

Enables low-density lipoprotein particle receptor activity. Involved in embryo development; oocyte development; and ovulation. Located in endosome membrane and plasma membrane. Expressed in germ cell; germ line; and gonad. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; female reproductive organ cancer (multiple); hepatobiliary system cancer (multiple); and high grade glioma (multiple). Is an ortholog of human EGF (epidermal growth factor).

T13A10.64

Caenorhabditis elegans

Enriched in several structures, including ABalpppappp; ABalppppppp; ABplapaaaap; ABpraaaappp; and RME based on single-cell RNA-seq and RNA-seq studies. Is affected by adr-1 and ogt-1 based on RNA-seq studies.

snx-1

Caenorhabditis elegans

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity. Involved in several processes, including mechanosensory behavior; protein localization to postsynaptic membrane; and vesicle-mediated transport. Located in early endosome and early phagosome. Expressed in body wall musculature; gonadal sheath cell; head; hypodermis; and tail. Is an ortholog of human SNX1 (sorting nexin 1) and SNX2 (sorting nexin 2).

C32B5.18

Caenorhabditis elegans

Enriched in several structures, including DB neuron; RME; anterior hypodermis; interfacial epithelial cell; and pharyngeal muscle cell based on single-cell RNA-seq studies. Is affected by several genes including ash-2; mrps-5; and spr-1 based on microarray and RNA-seq studies. Is affected by five chemicals including Psoralens; allantoin; and metformin based on RNA-seq studies.

rabn-5

Caenorhabditis elegans

Enables GTPase activating protein binding activity. Involved in molting cycle. Is an ortholog of human RABEP1 (rabaptin, RAB GTPase binding effector protein 1).

T23F6.3

Caenorhabditis elegans

Enriched in several structures, including ABalaapppp; ABalapaapp; ABalappppa; ABalppappp; and RME based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including nuo-6; atfs-1; and etr-1 based on microarray; RNA-seq; and tiling array studies. Is affected by twenty-three chemicals including Ethanol; methylmercury hydroxide; and methylmercuric chloride based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domain: Zinc finger, RING/FYVE/PHD-type.

alx-1

Caenorhabditis elegans

Enables Notch binding activity. Involved in several processes, including endocytic recycling; endosome organization; and regulation of protein catabolic process. Located in basolateral plasma membrane; multivesicular body; and recycling endosome. Expressed in several structures, including vulva. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Is an ortholog of human PDCD6IP (programmed cell death 6 interacting protein).