rab-35

Caenorhabditis elegans

Enables GTPase activating protein binding activity and ankyrin repeat binding activity. Involved in endocytic recycling. Located in early endosome; plasma membrane; and recycling endosome membrane. Expressed in several structures, including oocyte. Is an ortholog of human RAB35 (RAB35, member RAS oncogene family).

rme-6

Caenorhabditis elegans

Enables small GTPase binding activity. Involved in endocytosis; molting cycle; and regulation of clathrin-dependent endocytosis. Located in clathrin-coated endocytic vesicle; early endosome; and plasma membrane. Expressed in several structures, including anterior gonad arm; coelomocyte; intestine; oocyte; and pharynx. Is an ortholog of human GAPVD1 (GTPase activating protein and VPS9 domains 1).

rabn-5

Caenorhabditis elegans

Enables GTPase activating protein binding activity. Involved in molting cycle. Is an ortholog of human RABEP1 (rabaptin, RAB GTPase binding effector protein 1).

rme-8

Caenorhabditis elegans

Enables identical protein binding activity. Involved in several processes, including mechanosensory behavior; positive regulation of nematode male tail tip morphogenesis; and vesicle-mediated transport. Located in endosome. Expressed in coelomocyte; hypodermal cell; muscle cell; oocyte; and uterus. Human ortholog(s) of this gene implicated in Parkinson's disease. Is an ortholog of human DNAJC13 (DnaJ heat shock protein family (Hsp40) member C13).

rme-1

Caenorhabditis elegans

Enables ATP hydrolysis activity and protein domain specific binding activity. Involved in several processes, including endocytic recycling; lipid tube assembly involved in organelle fission; and necroptotic process. Located in recycling endosome membrane. Expressed in coelomocyte; germ line; gonad; intestine; and pharynx. Is an ortholog of human EHD1 (EH domain containing 1).

C32B5.18

Caenorhabditis elegans

Enriched in several structures, including DB neuron; RME; anterior hypodermis; interfacial epithelial cell; and pharyngeal muscle cell based on single-cell RNA-seq studies. Is affected by several genes including ash-2; mrps-5; and spr-1 based on microarray and RNA-seq studies. Is affected by five chemicals including Psoralens; allantoin; and metformin based on RNA-seq studies.

rabx-5

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in endosomal vesicle fusion and molting cycle. Located in early endosome. Expressed in several structures, including coelomocyte; distal tip cell; neurons; ventral nerve cord; and vulva. Is an ortholog of human RABGEF1 (RAB guanine nucleotide exchange factor 1).

rme-2

Caenorhabditis elegans

Enables low-density lipoprotein particle receptor activity. Involved in embryo development; oocyte development; and ovulation. Located in endosome membrane and plasma membrane. Expressed in germ cell; germ line; and gonad. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; female reproductive organ cancer (multiple); hepatobiliary system cancer (multiple); and high grade glioma (multiple). Is an ortholog of human EGF (epidermal growth factor).

T13A10.64

Caenorhabditis elegans

Enriched in several structures, including ABalpppappp; ABalppppppp; ABplapaaaap; ABpraaaappp; and RME based on single-cell RNA-seq and RNA-seq studies. Is affected by adr-1 and ogt-1 based on RNA-seq studies.

snx-1

Caenorhabditis elegans

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity. Involved in several processes, including mechanosensory behavior; protein localization to postsynaptic membrane; and vesicle-mediated transport. Located in early endosome and early phagosome. Expressed in body wall musculature; gonadal sheath cell; head; hypodermis; and tail. Is an ortholog of human SNX1 (sorting nexin 1) and SNX2 (sorting nexin 2).