ric-1

Caenorhabditis elegans

Acts upstream of or within cholinergic synaptic transmission.

rpl-7A

Caenorhabditis elegans

Enables calmodulin binding activity. Predicted to be involved in maturation of LSU-rRNA. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Is an ortholog of human RPL7A (ribosomal protein L7a).

ric-8

Caenorhabditis elegans

Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including negative regulation of protein kinase C signaling; protein localization to cell cortex; and regulation of feeding behavior. Located in aster; cell cortex; and kinetochore microtubule. Expressed in germ line and neurons. Is an ortholog of human RIC8A (RIC8 guanine nucleotide exchange factor A).

ric-4

Caenorhabditis elegans

Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in cholinergic synaptic transmission. Located in plasma membrane and synapse. Expressed in several structures, including CAN; excretory gland cell; mechanosensory neurons; rectal gland cell; and somatic nervous system. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Is an ortholog of human SNAP25 (synaptosome associated protein 25).

ric-3

Caenorhabditis elegans

Enables protein folding chaperone. Involved in several processes, including cholinergic synaptic transmission; positive regulation of cholinergic synaptic transmission; and protein localization to cell surface. Located in intracellular membrane-bounded organelle; neuron projection; and neuronal cell body. Expressed in body wall musculature; neurons; and pharyngeal muscle cell. Is an ortholog of human RIC3 (RIC3 acetylcholine receptor chaperone).

ric-6

Caenorhabditis elegans

clec-196

Caenorhabditis elegans

Predicted to enable carbohydrate binding activity. Predicted to be located in external side of plasma membrane. Human ortholog(s) of this gene implicated in aspergillosis and chronic mucocutaneous candidiasis. Is an ortholog of human CLEC7A (C-type lectin domain containing 7A).

ttc-7

Caenorhabditis elegans

Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in multiple intestinal atresia. Is an ortholog of human TTC7A (tetratricopeptide repeat domain 7A) and TTC7B (tetratricopeptide repeat domain 7B).

bath-42

Caenorhabditis elegans

Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of proteolysis. Predicted to be located in cytoplasm and nucleus. Expressed in intestine; pharyngeal muscle cell; seam cell; and vulval muscle.

Y60C6A.3

Caenorhabditis elegans

Enriched in RIC and RICL based on single-cell RNA-seq studies. Is affected by several genes including lsl-1; hsf-1; and lpd-3 based on RNA-seq and microarray studies. Is affected by fifteen chemicals including stearic acid; sucrose; and cyclobutrifluram based on RNA-seq and microarray studies.