ric-3

Caenorhabditis elegans

Enables protein folding chaperone. Involved in several processes, including cholinergic synaptic transmission; positive regulation of cholinergic synaptic transmission; and protein localization to cell surface. Located in intracellular membrane-bounded organelle; neuron projection; and neuronal cell body. Expressed in body wall musculature; neurons; and pharyngeal muscle cell. Is an ortholog of human RIC3 (RIC3 acetylcholine receptor chaperone).

bath-42

Caenorhabditis elegans

Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of proteolysis. Predicted to be located in cytoplasm and nucleus. Expressed in intestine; pharyngeal muscle cell; seam cell; and vulval muscle.

ric-1

Caenorhabditis elegans

Acts upstream of or within cholinergic synaptic transmission.

ric-8

Caenorhabditis elegans

Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including negative regulation of protein kinase C signaling; protein localization to cell cortex; and regulation of feeding behavior. Located in aster; cell cortex; and kinetochore microtubule. Expressed in germ line and neurons. Is an ortholog of human RIC8A (RIC8 guanine nucleotide exchange factor A).

ric-4

Caenorhabditis elegans

Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in cholinergic synaptic transmission. Located in plasma membrane and synapse. Expressed in several structures, including CAN; excretory gland cell; mechanosensory neurons; rectal gland cell; and somatic nervous system. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Is an ortholog of human SNAP25 (synaptosome associated protein 25).

B0222.10

Caenorhabditis elegans

Enriched in several structures, including ABalaaaala; ABalaapaaa; RIC; interfacial epithelial cell; and rect_D based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including drh-3; rrf-3; and mrps-5 based on microarray and RNA-seq studies. Is affected by thirteen chemicals including Alovudine; stavudine; and Psoralens based on RNA-seq and microarray studies.

Y60C6A.3

Caenorhabditis elegans

Enriched in RIC and RICL based on single-cell RNA-seq studies. Is affected by several genes including lsl-1; hsf-1; and lpd-3 based on RNA-seq and microarray studies. Is affected by fifteen chemicals including stearic acid; sucrose; and cyclobutrifluram based on RNA-seq and microarray studies.

ric-6

Caenorhabditis elegans

K09E3.7

Caenorhabditis elegans

Enriched in RIC; germ line; oocyte; rectal epithelium; and ut4 based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including cyc-1; swsn-1; and puf-8 based on microarray; RNA-seq; and tiling array studies. Is affected by twenty-one chemicals including lithium chloride; D-glucose; and Alovudine based on microarray; RNA-seq; and proteomic studies.

gpr-1

Caenorhabditis elegans

Enables G-protein alpha-subunit binding activity and GDP-dissociation inhibitor activity. Predicted to be involved in cell division. Located in aster and cell cortex. Expressed in P lineage cell.