snt-1

Caenorhabditis elegans

Enables calcium ion binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Involved in several processes, including defecation; regulation of nematode pharyngeal pumping; and synaptic vesicle endocytosis. Located in synaptic vesicle. Expressed in several structures, including excretory gland cell; gonad; nervous system; pharyngeal gland cell; and rectal gland cell. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 7. Is an ortholog of human SYT1 (synaptotagmin 1).

ric-1

Caenorhabditis elegans

Acts upstream of or within cholinergic synaptic transmission.

ric-8

Caenorhabditis elegans

Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including negative regulation of protein kinase C signaling; protein localization to cell cortex; and regulation of feeding behavior. Located in aster; cell cortex; and kinetochore microtubule. Expressed in germ line and neurons. Is an ortholog of human RIC8A (RIC8 guanine nucleotide exchange factor A).

ric-4

Caenorhabditis elegans

Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in cholinergic synaptic transmission. Located in plasma membrane and synapse. Expressed in several structures, including CAN; excretory gland cell; mechanosensory neurons; rectal gland cell; and somatic nervous system. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Is an ortholog of human SNAP25 (synaptosome associated protein 25).

ric-3

Caenorhabditis elegans

Enables protein folding chaperone. Involved in several processes, including cholinergic synaptic transmission; positive regulation of cholinergic synaptic transmission; and protein localization to cell surface. Located in intracellular membrane-bounded organelle; neuron projection; and neuronal cell body. Expressed in body wall musculature; neurons; and pharyngeal muscle cell. Is an ortholog of human RIC3 (RIC3 acetylcholine receptor chaperone).

ric-6

Caenorhabditis elegans

gpr-1

Caenorhabditis elegans

Enables G-protein alpha-subunit binding activity and GDP-dissociation inhibitor activity. Predicted to be involved in cell division. Located in aster and cell cortex. Expressed in P lineage cell.

bath-42

Caenorhabditis elegans

Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of proteolysis. Predicted to be located in cytoplasm and nucleus. Expressed in intestine; pharyngeal muscle cell; seam cell; and vulval muscle.

Y60C6A.3

Caenorhabditis elegans

Enriched in RIC and RICL based on single-cell RNA-seq studies. Is affected by several genes including lsl-1; hsf-1; and lpd-3 based on RNA-seq and microarray studies. Is affected by fifteen chemicals including stearic acid; sucrose; and cyclobutrifluram based on RNA-seq and microarray studies.

T02H6.5

Caenorhabditis elegans

Enriched in RIC; excretory cell; and rectal epithelial cell based on tiling array and single-cell RNA-seq studies. Is affected by several genes including swsn-1; etr-1; and csr-1 based on RNA-seq and microarray studies. Is affected by nine chemicals including methylmercuric chloride; Alovudine; and Psoralens based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: F-box associated; F-box domain; and F-box associated domain, type 2.