Bma-rhi-1

Brugia malayi

Predicted to enable Rho GDP-dissociation inhibitor activity. Predicted to be involved in Rho protein signal transduction. Predicted to be located in cytoplasm. Is an ortholog of C. elegans rhi-1.

Bm359

Brugia malayi

Is predicted to encode a protein with the following domains: CRIB domain superfamily; P21-Rho-binding domain; and CRIB domain.

Bma-rho-1.1

Brugia malayi

Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in small GTPase-mediated signal transduction. Is an ortholog of C. elegans rho-1. In C. elegans, rho-1 is involved in several processes, including actomyosin structure organization; positive regulation of acetylcholine secretion, neurotransmission; and positive regulation of locomotion.

Bma-rho-1.2

Brugia malayi

Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in small GTPase-mediated signal transduction. Is an ortholog of C. elegans rho-1. In C. elegans, rho-1 is involved in several processes, including actomyosin structure organization; positive regulation of acetylcholine secretion, neurotransmission; and positive regulation of locomotion.

Bm5525

Brugia malayi

Predicted to enable actin binding activity. Predicted to be involved in positive regulation of Rho protein signal transduction. Is an ortholog of C. elegans tag-243.

Bma-gap-2

Brugia malayi

Is affected by ivermectin based on RNA-seq studies. Is predicted to encode a protein with the following domains: Ras GTPase-activating protein; C2 domain; Rho GTPase activation protein; GTPase-activator protein for Ras-like GTPase; Ras GTPase-activating domain; and C2 domain superfamily. Is an ortholog of C. elegans gap-2. In C. elegans, gap-2 is involved in learning or memory and negative regulation of Ras protein signal transduction.

Bm9765

Brugia malayi

Is predicted to encode a protein with the following domains: Rho GTPase activation protein; SH2 domain superfamily; SH3-like domain superfamily; SH3 domain; SH2 domain; and PH-like domain superfamily. Is an ortholog of O. volvulus Ovo-gap-3.

Bma-ctn-1

Brugia malayi

Predicted to enable actin filament binding activity and cadherin binding activity. Predicted to be involved in Rho protein signal transduction and cell adhesion. Is an ortholog of C. elegans ctn-1. In C. elegans, ctn-1 is involved in regulation of locomotion.

Bma-pes-7

Brugia malayi

Is predicted to encode a protein with the following domains: Calponin homology (CH) domain; Calponin homology domain; Rho GTPase activation protein; GTPase-activator protein for Ras-like GTPase; RasGAP C-terminus; Ras GTPase-activating domain; RasGAP protein, C-terminal; and CH domain superfamily. Is an ortholog of C. elegans pes-7.

Bma-gpa-12

Brugia malayi

Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; GTPase activity; and guanyl nucleotide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and Rho protein signal transduction. Is an ortholog of C. elegans gpa-12. In C. elegans, gpa-12 is involved in antifungal innate immune response and positive regulation of gene expression.