rhgf-2

Caenorhabditis elegans

Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including Rho protein signal transduction; embryonic body morphogenesis; and positive regulation of transcription by RNA polymerase II. Located in axon and cell body. Expressed in several structures, including pharyngeal cell; seam cell; somatic nervous system; tail; and touch receptor neurons. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate C and autosomal recessive distal hereditary motor neuronopathy 4. Is an ortholog of human PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5).

rhgf-1

Caenorhabditis elegans

Enables microtubule binding activity. Involved in axon regeneration. Located in neuronal cell body and varicosity. Expressed in nervous system and spermatheca. Human ortholog(s) of this gene implicated in immunodeficiency 62. Is an ortholog of human ARHGEF11 (Rho guanine nucleotide exchange factor 11).

trpp-11

Caenorhabditis elegans

Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2S. Is an ortholog of human TRAPPC11 (trafficking protein particle complex subunit 11).

cisd-3.2

Caenorhabditis elegans

Predicted to enable 2 iron, 2 sulfur cluster binding activity. Predicted to be involved in protein maturation by [2Fe-2S] cluster transfer. Predicted to be located in mitochondrion. Is an ortholog of human CISD3 (CDGSH iron sulfur domain 3).

cisd-3.1

Caenorhabditis elegans

Predicted to enable 2 iron, 2 sulfur cluster binding activity. Predicted to be involved in protein maturation by [2Fe-2S] cluster transfer. Predicted to be located in mitochondrion. Is an ortholog of human CISD3 (CDGSH iron sulfur domain 3).

dnj-15

Caenorhabditis elegans

Predicted to enable ATPase activator activity and protein-folding chaperone binding activity. Predicted to be involved in [2Fe-2S] cluster assembly. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in sideroblastic anemia. Is an ortholog of human HSCB (HscB mitochondrial iron-sulfur cluster cochaperone).

Y106G6D.5

Caenorhabditis elegans

Predicted to enable RNA binding activity and transcription termination site sequence-specific DNA binding activity. Predicted to be involved in termination of RNA polymerase II transcription. Predicted to be located in nuclear body. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2S and autosomal recessive distal hereditary motor neuronopathy 1. Is an ortholog of human IGHMBP2 (immunoglobulin mu DNA binding protein 2).

mpz-1

Caenorhabditis elegans

Enables GTPase activating protein binding activity. Located in axon. Expressed in body wall musculature; nerve ring; neurons; and vulval muscle. Human ortholog(s) of this gene implicated in hydrocephalus. Is an ortholog of human MPDZ (multiple PDZ domain crumbs cell polarity complex component) and PATJ (PATJ crumbs cell polarity complex component).