rde-1

Caenorhabditis elegans

Enables DEAD/H-box RNA helicase binding activity; RNA endonuclease activity, producing 5'-phosphomonoesters; and siRNA binding activity. Involved in regulatory ncRNA-mediated heterochromatin formation and regulatory ncRNA-mediated post-transcriptional gene silencing. Part of RISC complex. Expressed in male.

rde-2

Caenorhabditis elegans

Involved in meiotic chromosome segregation; regulatory ncRNA-mediated post-transcriptional gene silencing; and siRNA processing. Located in cytosol and mutator focus. Expressed in germ line.

rde-4

Caenorhabditis elegans

Enables double-stranded RNA binding activity; protein homodimerization activity; and single-stranded RNA binding activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing and siRNA processing. Part of ribonucleoprotein complex. Human ortholog(s) of this gene implicated in dystonia 16. Is an ortholog of human PRKRA (protein activator of interferon induced protein kinase EIF2AK2) and TARBP2 (TARBP2 subunit of RISC loading complex).

dec-9

Caenorhabditis elegans

T23B3.8

Caenorhabditis elegans

Enriched in neurons based on RNA-seq and microarray studies. Is affected by several genes including etr-1; sir-2.1; and rde-1 based on RNA-seq and microarray studies. Is affected by fluoranthene based on microarray studies.

lpd-9

Caenorhabditis elegans

Involved in lipid storage. Predicted to be located in membrane.

mut-9

Caenorhabditis elegans

txdc-9

Caenorhabditis elegans

Involved in microtubule cytoskeleton organization. Located in cytoplasm and nucleus. Expressed in nervous system; pharynx; and vulva. Is an ortholog of human TXNDC9 (thioredoxin domain containing 9).

let-9

Caenorhabditis elegans

ins-9

Caenorhabditis elegans

Predicted to enable hormone activity. Predicted to be involved in signal transduction. Predicted to be located in extracellular region. Expressed in coelomocyte; intestine; nerve ring; and neurons.