Involved in meiotic chromosome segregation; regulatory ncRNA-mediated post-transcriptional gene silencing; and siRNA processing. Located in cytosol and mutator focus. Expressed in germ line.
Enables double-stranded RNA binding activity; protein homodimerization activity; and single-stranded RNA binding activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing and siRNA processing. Part of ribonucleoprotein complex. Human ortholog(s) of this gene implicated in dystonia 16. Is an ortholog of human PRKRA (protein activator of interferon induced protein kinase EIF2AK2) and TARBP2 (TARBP2 subunit of RISC loading complex).
Enriched in neurons based on RNA-seq and microarray studies. Is affected by several genes including etr-1; sir-2.1; and rde-1 based on RNA-seq and microarray studies. Is affected by fluoranthene based on microarray studies.
Predicted to enable ATP binding activity; helicase activity; and nucleic acid binding activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome and primary immunodeficiency disease. Is an ortholog of human RIGI (RNA sensor RIG-I).
Predicted to enable 3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing. Involved in olfactory learning and regulatory ncRNA-mediated post-transcriptional gene silencing. Located in cytosol; mutator focus; and nucleus. Expressed in AWCL; AWCR; and somatic cell. Is an ortholog of human EXD3 (exonuclease 3'-5' domain containing 3).
Predicted to enable RNA endonuclease activity and single-stranded RNA binding activity. Predicted to be involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be located in cytoplasmic ribonucleoprotein granule and nucleus. Predicted to be part of RISC complex. Expressed in male.
Enables RNA binding activity and RNA endonuclease activity. Involved in embryo development; nematode larval development; and regulatory ncRNA-mediated gene silencing. Located in cytoplasm. Part of RISC complex. Expressed in several structures, including gonad; hypodermis; neurons; somatic cell; and ventral nerve cord. Human ortholog(s) of this gene implicated in alcohol dependence and glaucoma. Is an ortholog of human AGO2 (argonaute RISC catalytic component 2).