rad-54.L

Caenorhabditis elegans

Enables ATP-dependent activity, acting on DNA. Predicted to be involved in double-strand break repair via synthesis-dependent strand annealing and reciprocal meiotic recombination. Located in nucleus. Human ortholog(s) of this gene implicated in breast cancer; non-Hodgkin lymphoma; and pancreatic cancer. Is an ortholog of human RAD54L (RAD54 like).

rad-54.B

Caenorhabditis elegans

Predicted to enable DNA translocase activity. Predicted to be involved in double-strand break repair via homologous recombination and reciprocal meiotic recombination. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in colorectal cancer and non-Hodgkin lymphoma. Is an ortholog of human RAD54B (RAD54 homolog B).

rad-54.L2

Caenorhabditis elegans

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and SUMO binding activity. Involved in negative regulation of vulval development. Predicted to be located in nucleus. Predicted to be part of NuRD complex. Is an ortholog of human RAD54L2 (RAD54 like 2).

rad-23

Caenorhabditis elegans

Predicted to enable polyubiquitin modification-dependent protein binding activity; proteasome binding activity; and ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Expressed in dorsal nerve cord; head; neurons; ventral nerve cord; and vulva. Is an ortholog of human RAD23A (RAD23 homolog A, nucleotide excision repair protein).

K11D12.6

Caenorhabditis elegans

Predicted to enable serine-type endopeptidase inhibitor activity.

rad-8

Caenorhabditis elegans

Predicted to enable NADPH dehydrogenase (quinone) activity. Involved in several processes, including defense response to other organism; positive regulation of growth rate; and response to superoxide. Located in mitochondrion. Expressed in several structures, including intestine; muscle cell; neurons; and pharynx. Human ortholog(s) of this gene implicated in optic atrophy 10. Is an ortholog of human RTN4IP1 (reticulon 4 interacting protein 1).

rad-7

Caenorhabditis elegans

Acts upstream of or within response to UV.

gst-5

Caenorhabditis elegans

Predicted to enable glutathione transferase activity. Involved in innate immune response. Expressed in intestine and nerve ring. Is an ortholog of human HPGDS (hematopoietic prostaglandin D synthase).

rad-9

Caenorhabditis elegans

Acts upstream of or within embryo development and response to UV.

brc-2

Caenorhabditis elegans

Enables single-stranded DNA binding activity. Involved in several processes, including DNA metabolic process; egg-laying behavior; and embryo development. Located in condensed nuclear chromosome.