rac-2

Caenorhabditis elegans

Enables GTP binding activity and GTPase activity. Involved in actin filament organization and generation of neurons. Located in axon and plasma membrane. Expressed in nerve ring and neurons. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant intellectual developmental disorder 48; colon adenoma; and gastrointestinal system cancer (multiple). Is an ortholog of human RAC1 (Rac family small GTPase 1).

swan-1

Caenorhabditis elegans

Enables LIM domain binding activity and small GTPase binding activity. Involved in negative regulation of cell migration; regulation of cellular component organization; and response to stress. Located in cytoplasm. Expressed in several structures, including neuroblasts and neurons. Is an ortholog of human DCAF7 (DDB1 and CUL4 associated factor 7).

pix-1

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in gonad morphogenesis; inductive cell migration; and neuron migration. Located in anchoring junction; cell periphery; and cytoplasm. Expressed in hermaphrodite gonad; hypodermis; and somatic gonad precursor. Human ortholog(s) of this gene implicated in intellectual disability. Is an ortholog of human ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

git-1

Caenorhabditis elegans

Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in gonad morphogenesis and inductive cell migration. Located in hemidesmosome and presynaptic active zone. Human ortholog(s) of this gene implicated in Huntington's disease and attention deficit hyperactivity disorder. Is an ortholog of human GIT2 (GIT ArfGAP 2).

rhgf-3

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rho protein signal transduction. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with midbrain and hindbrain malformations. Is an ortholog of human ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2).

rga-8

Caenorhabditis elegans

Predicted to enable GTPase activator activity. Predicted to be involved in regulation of Rac protein signal transduction and regulation of actin cytoskeleton organization. Human ortholog(s) of this gene implicated in acquired immunodeficiency syndrome; carcinoma (multiple); and skin melanoma. Is an ortholog of human ARHGAP17 (Rho GTPase activating protein 17); ARHGAP44 (Rho GTPase activating protein 44); and SH3BP1 (SH3 domain binding protein 1).

crml-1

Caenorhabditis elegans

Enables GTPase activating protein binding activity. Involved in several processes, including axon guidance; negative regulation of Rac protein signal transduction; and regulation of axon extension involved in axon guidance. Located in plasma membrane. Expressed in several structures, including distal tip cell; epithelial cell; excretory canal; neurons; and vulva. Human ortholog(s) of this gene implicated in immunodeficiency 58. Is an ortholog of human CARMIL1 (capping protein regulator and myosin 1 linker 1); CARMIL2 (capping protein regulator and myosin 1 linker 2); and CARMIL3 (capping protein regulator and myosin 1 linker 3).

nrde-4

Caenorhabditis elegans

Involved in regulatory ncRNA-mediated post-transcriptional gene silencing.

F09F7.5

Caenorhabditis elegans

Predicted to enable small GTPase binding activity. Predicted to be involved in regulation of Rho protein signal transduction and regulation of cell shape. Predicted to be located in cytoskeleton and plasma membrane. Is an ortholog of human CDC42SE1 (CDC42 small effector 1) and CDC42SE2 (CDC42 small effector 2).

sos-1

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; female gamete generation; and positive regulation of vulval development. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 4; Noonan syndrome 9; and reproductive organ cancer (multiple). Is an ortholog of human SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1).