unc-108

Caenorhabditis elegans

Enables GTPase activity. Involved in several processes, including dense core granule maturation; phagosome maturation involved in apoptotic cell clearance; and regulation of locomotion involved in locomotory behavior. Located in axon; cytoplasm; and neuronal cell body. Expressed in several structures, including excretory gland cell; hermaphrodite somatic gonadal cell; neurons; pharyngeal gland cell; and rectal gland cell. Is an ortholog of human RAB2A (RAB2A, member RAS oncogene family).

M57.2

Caenorhabditis elegans

Predicted to enable protein prenyltransferase activity. Predicted to contribute to Rab geranylgeranyltransferase activity. Predicted to be involved in prenylation. Predicted to be located in cytoplasm. Predicted to be part of Rab-protein geranylgeranyltransferase complex. Is an ortholog of human RABGGTA (Rab geranylgeranyltransferase subunit alpha).

rab-14

Caenorhabditis elegans

Predicted to enable GTPase activity. Involved in phagolysosome assembly involved in apoptotic cell clearance and phagosome acidification involved in apoptotic cell clearance. Located in early endosome; phagocytic vesicle; and trans-Golgi network. Expressed in gonadal sheath cell; hypodermis; intestine; and pharyngeal muscle cell. Is an ortholog of human RAB14 (RAB14, member RAS oncogene family).

rab-6.1

Caenorhabditis elegans

Predicted to enable GTPase activity. Involved in cortical granule exocytosis and cuticle development. Located in Golgi cisterna and cortical granule. Expressed in several structures, including RIG; command interneuron; gonad; intestine; and vulva. Is an ortholog of human RAB6A (RAB6A, member RAS oncogene family).

ggtb-1

Caenorhabditis elegans

Predicted to enable small GTPase binding activity and zinc ion binding activity. Predicted to contribute to Rab geranylgeranyltransferase activity. Involved in PERK-mediated unfolded protein response. Predicted to be part of Rab-protein geranylgeranyltransferase complex. Expressed in head; intestine; and tail. Is an ortholog of human RABGGTB (Rab geranylgeranyltransferase subunit beta).

rep-1

Caenorhabditis elegans

Predicted to enable GTPase activator activity and Rab GDP-dissociation inhibitor activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in cytosol and nucleus. Predicted to be part of Rab-protein geranylgeranyltransferase complex. Expressed in alimentary muscle; body wall musculature; hypodermis; and neurons. Human ortholog(s) of this gene implicated in asthma and choroideremia. Is an ortholog of human CHM (CHM Rab escort protein) and CHML (CHM like Rab escort protein).

rab-6.2

Caenorhabditis elegans

Enables GTP binding activity. Involved in several processes, including early endosome to Golgi transport; positive regulation of feeding behavior; and protein stabilization. Located in Golgi trans cisterna. Expressed in several structures, including coelomocyte; command interneuron; gonad; pharynx; and vulva. Is an ortholog of human RAB6A (RAB6A, member RAS oncogene family) and RAB6B (RAB6B, member RAS oncogene family).

rab-21

Caenorhabditis elegans

Predicted to enable GTPase activity. Predicted to be involved in intracellular protein transport. Predicted to be located in early endosome. Is an ortholog of human RAB21 (RAB21, member RAS oncogene family).

rab-7

Caenorhabditis elegans

Enables GTPase activity. Involved in several processes, including oocyte growth; positive regulation of early endosome to late endosome transport; and vesicle-mediated transport. Located in late endosome membrane; lysosome; and phagocytic vesicle membrane. Expressed in several structures, including oocyte. Used to study obesity. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B. Is an ortholog of human RAB7A (RAB7A, member RAS oncogene family).

rab-5

Caenorhabditis elegans

Enables GTPase activating protein binding activity and GTPase activity. Involved in embryo development; protein localization; and vesicle-mediated transport. Located in several cellular components, including cholinergic synapse; cytoplasmic vesicle; and periciliary membrane compartment. Expressed in several structures, including ventral cord neurons. Is an ortholog of human RAB5B (RAB5B, member RAS oncogene family) and RAB5C (RAB5C, member RAS oncogene family).