Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including dorsal/ventral axon guidance; nematode larval development; and regulation of GABAergic synaptic transmission. Predicted to be located in cytoplasm. Expressed in several structures, including QL; QR; body wall musculature; pharynx; and somatic nervous system. Used to study epilepsy. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive intellectual developmental disorder 54; gastrointestinal system cancer (multiple); and hepatitis B. Is an ortholog of human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4); MINK1 (misshapen like kinase 1); and TNIK (TRAF2 and NCK interacting kinase).
Enables peroxidase activity. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle; nematode larval development; and post-embryonic body morphogenesis. Predicted to be located in extracellular space. Expressed in anterior hypodermis and hypodermal cell.
Predicted to enable 7-dehydrocholesterol reductase activity. Predicted to be involved in brassinosteroid biosynthetic process and cholesterol biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in several diseases, including Greenberg dysplasia; Pelger-Huet anomaly; and autoimmune disease (multiple). Is an ortholog of human DHCR7 (7-dehydrocholesterol reductase).
Located in plasma membrane. Expressed in body wall musculature; hypodermis; pharynx; and vulva. Is an ortholog of human MEAK7 (MTOR associated protein, eak-7 homolog).