Enables ubiquitin binding activity. Involved in several processes, including ephrin receptor signaling pathway; protein localization to non-motile cilium; and response to hermaphrodite contact. Located in cilium and early endosome. Part of ESCRT-0 complex. Expressed in CEM; male gonad; neurons; and pharyngeal-intestinal valve. Used to study polycystic kidney disease. Is an ortholog of human STAM (signal transducing adaptor molecule).
Predicted to enable chitin binding activity. Involved in endoplasmic reticulum unfolded protein response. Predicted to be located in extracellular region.
Enables cohesin loader activity. Involved in several processes, including chromosome organization; double-strand break repair involved in meiotic recombination; and regulation of cell cycle process. Located in chromosome and nucleus. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 1. Is an ortholog of human NIPBL (NIPBL cohesin loading factor).
Enriched in somatic gonad precursor based on RNA-seq studies. Is affected by pqn-59 based on proteomic studies. Is affected by rifampin based on RNA-seq studies.