Enables protein phosphatase 2B binding activity. Predicted to be involved in protein transport. Predicted to be located in cytoplasm. Expressed in nervous system.
Predicted to enable translation initiation factor activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 2. Is an ortholog of human EIF2B2 (eukaryotic translation initiation factor 2B subunit beta).
Enables identical protein binding activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 1. Is an ortholog of human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha).
Enables MAP kinase activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including behavioral response to nicotine; positive regulation of macromolecule biosynthetic process; and response to stress. Located in cytosol and nucleus. Expressed in several structures, including germ line; head neurons; intestine; and vulval precursor cell. Used to study Parkinson's disease and cardiovascular system disease. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple). Is an ortholog of human MAPK11 (mitogen-activated protein kinase 11) and MAPK14 (mitogen-activated protein kinase 14).
Is affected by several genes including etr-1; smg-2; and pmk-1 based on RNA-seq and microarray studies. Is affected by dibromoacetic acid based on microarray studies.
Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including behavioral response to nicotine; regulation of axon extension; and response to stress. Located in cytoplasm and nucleus. Expressed in several structures, including amphid neurons; gonad; and intestine.
Is affected by several genes including rrf-1; pmk-1; and glh-4 based on RNA-seq and microarray studies. Is affected by Atrazine and cadmium based on microarray studies.
Is affected by several genes including pmk-1; oga-1; and ogt-1 based on microarray studies. Is affected by four chemicals including Testosterone; Colistin; and dafa#1 based on microarray studies.