Enables NAD+ ADP-ribosyltransferase activity. Involved in determination of adult lifespan. Predicted to be located in nucleolus. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; idiopathic pulmonary fibrosis; and perinatal necrotizing enterocolitis. Is an ortholog of human PARP1 (poly(ADP-ribose) polymerase 1).
Predicted to enable pseudouridine synthase activity. Predicted to be involved in mRNA pseudouridine synthesis and tRNA pseudouridine synthesis. Predicted to be located in cytoplasm and nucleus. Is an ortholog of human PUS3 (pseudouridine synthase 3).
Predicted to enable ATP binding activity and adenylate kinase activity. Predicted to be involved in nucleoside monophosphate phosphorylation; rRNA processing; and ribosomal small subunit biogenesis. Predicted to be located in cytoplasm and nucleus. Is an ortholog of human AK6 (adenylate kinase 6).
Predicted to enable RNA binding activity. Predicted to be involved in tRNA splicing, via endonucleolytic cleavage and ligation. Predicted to be part of tRNA-splicing ligase complex. Is an ortholog of human RTRAF (RNA transcription, translation and transport factor).
Predicted to enable NAD+ ADP-ribosyltransferase activity and NAD+-protein ADP-ribosyltransferase activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of programmed cell death; and response to gamma radiation. Located in nucleus.
Enables poly(ADP-ribose) glycohydrolase activity. Involved in nucleotide-sugar metabolic process and response to gamma radiation. Located in neuron projection and nucleus. Expressed in tail neurons and ventral cord neurons. Is an ortholog of human BPHL (biphenyl hydrolase like) and PARG (poly(ADP-ribose) glycohydrolase).
Enables NAD+ ADP-ribosyltransferase activity. Predicted to be involved in double-strand break repair. Predicted to be located in nucleolus. Is an ortholog of human PARP2 (poly(ADP-ribose) polymerase 2).
Enables poly(ADP-ribose) glycohydrolase activity. Involved in nucleotide-sugar metabolic process and response to gamma radiation. Located in cytoplasm. Expressed in head neurons and tail neurons. Is an ortholog of human BPHL (biphenyl hydrolase like) and PARG (poly(ADP-ribose) glycohydrolase).