Enables diacylglycerol-dependent serine/threonine kinase activity. Involved in several processes, including nervous system process; regulation of presynaptic dense core granule exocytosis; and signaling. Located in cholinergic synapse and neuron projection. Expressed in ganglia; linker cell; and neurons. Human ortholog(s) of this gene implicated in cerebral infarction. Is an ortholog of human PRKCE (protein kinase C epsilon).
Enables protein domain specific binding activity and protein serine/threonine kinase activity. Involved in several processes, including embryo development; gonad development; and response to stress. Located in apical plasma membrane; cortical actin cytoskeleton; and cytosol. Expressed in several structures, including Psub4; enteric muscle; hypodermis; pharyngeal-intestinal valve; and vulva. Human ortholog(s) of this gene implicated in invasive ductal carcinoma and ovarian carcinoma. Is an ortholog of human PRKCI (protein kinase C iota) and PRKCZ (protein kinase C zeta).
Enables calcium,diacylglycerol-dependent serine/threonine kinase activity and protein serine kinase activity. Predicted to be involved in intracellular signal transduction. Located in several cellular components, including cytosol; neuron projection; and neuronal cell body. Expressed in body wall musculature; intestine; neurons; somatic nervous system; and tail ganglion. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; brain disease (multiple); carcinoma (multiple); and ductal carcinoma in situ. Is an ortholog of human PRKCA (protein kinase C alpha) and PRKCB (protein kinase C beta).
Predicted to enable GTPase activator activity; myosin II binding activity; and syntaxin binding activity. Involved in establishment of spindle orientation and protein localization. Located in basolateral plasma membrane and cell cortex. Expressed in epithelial cell; intestine; spermathecal cell; and vulval cell. Is an ortholog of human LLGL1 (LLGL scribble cell polarity complex component 1) and LLGL2 (LLGL scribble cell polarity complex component 2).