pkc-1

Caenorhabditis elegans

Enables diacylglycerol-dependent serine/threonine kinase activity. Involved in several processes, including nervous system process; regulation of presynaptic dense core granule exocytosis; and signaling. Located in cholinergic synapse and neuron projection. Expressed in ganglia; linker cell; and neurons. Human ortholog(s) of this gene implicated in cerebral infarction. Is an ortholog of human PRKCE (protein kinase C epsilon).

pkc-3

Caenorhabditis elegans

Enables protein domain specific binding activity and protein serine/threonine kinase activity. Involved in several processes, including embryo development; gonad development; and response to stress. Located in apical plasma membrane; cortical actin cytoskeleton; and cytosol. Expressed in several structures, including Psub4; enteric muscle; hypodermis; pharyngeal-intestinal valve; and vulva. Human ortholog(s) of this gene implicated in invasive ductal carcinoma and ovarian carcinoma. Is an ortholog of human PRKCI (protein kinase C iota) and PRKCZ (protein kinase C zeta).

pkc-2

Caenorhabditis elegans

Enables calcium,diacylglycerol-dependent serine/threonine kinase activity and protein serine kinase activity. Predicted to be involved in intracellular signal transduction. Located in several cellular components, including cytosol; neuron projection; and neuronal cell body. Expressed in body wall musculature; intestine; neurons; somatic nervous system; and tail ganglion. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; brain disease (multiple); carcinoma (multiple); and ductal carcinoma in situ. Is an ortholog of human PRKCA (protein kinase C alpha) and PRKCB (protein kinase C beta).

lgl-1

Caenorhabditis elegans

Predicted to enable GTPase activator activity; myosin II binding activity; and syntaxin binding activity. Involved in establishment of spindle orientation and protein localization. Located in basolateral plasma membrane and cell cortex. Expressed in epithelial cell; intestine; spermathecal cell; and vulval cell. Is an ortholog of human LLGL1 (LLGL scribble cell polarity complex component 1) and LLGL2 (LLGL scribble cell polarity complex component 2).

par-3

Caenorhabditis elegans

Predicted to enable phosphatidylinositol binding activity. Involved in several processes, including establishment of mitotic spindle orientation; gonad development; and polarity specification of anterior/posterior axis. Located in several cellular components, including P granule; basal part of cell; and cell cortex. Is extrinsic component of cytoplasmic side of plasma membrane. Expressed in several structures, including AB; Psub1; excretory cell; hermaphrodite gonad; and vulval cell. Is an ortholog of human PARD3B (par-3 family cell polarity regulator beta).

kup-1

Caenorhabditis elegans

Enriched in several structures, including AVK; MSaapaapa; accessory cell; anterior arcade cell; and g2 based on RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including cyd-1; cye-1; and atfs-1 based on microarray; tiling array; RNA-seq; and proteomic studies. Is affected by thirteen chemicals including rotenone; mianserin; and Zidovudine based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domain: Phosphorylation site.

par-2

Caenorhabditis elegans

Enables microtubule binding activity; phosphatidylinositol phosphate binding activity; and protein kinase binding activity. Involved in asymmetric cell division; asymmetric protein localization involved in cell fate determination; and establishment of mitotic spindle orientation. Located in P granule; posterior cell cortex; and protein-containing complex. Expressed in germ line.

num-1

Caenorhabditis elegans

Enables enzyme binding activity and protein domain specific binding activity. Involved in endocytic recycling; phospholipid transport; and protein targeting to membrane. Located in basolateral plasma membrane and cytoplasm. Expressed in several structures, including alimentary muscle; hermaphrodite gonad; nerve ring; pseudocoelom; and rectal valve cell. Is an ortholog of human NUMB (NUMB endocytic adaptor protein) and NUMBL (NUMB like endocytic adaptor protein).

spat-2

Caenorhabditis elegans

Enriched in germ line; germline precursor cell; head mesodermal cell; and neurons based on microarray; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including cyc-1; nuo-6; and atf-7 based on microarray; tiling array; proteomic; and RNA-seq studies. Is affected by seventeen chemicals including rotenone; Cry5B; and Alovudine based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domain: Phosphorylation site.

pac-1

Caenorhabditis elegans

Enables GTPase activator activity. Involved in protein localization; regulation of gastrulation; and small GTPase-mediated signal transduction. Located in cell junction. Expressed in anus; epithelial cell; hypodermis; pharynx; and pm7. Is an ortholog of human ARHGAP23 (Rho GTPase activating protein 23).