num-1

Caenorhabditis elegans

Enables enzyme binding activity and protein domain specific binding activity. Involved in endocytic recycling; phospholipid transport; and protein targeting to membrane. Located in basolateral plasma membrane and cytoplasm. Expressed in several structures, including alimentary muscle; hermaphrodite gonad; nerve ring; pseudocoelom; and rectal valve cell. Is an ortholog of human NUMB (NUMB endocytic adaptor protein) and NUMBL (NUMB like endocytic adaptor protein).

pkc-1

Caenorhabditis elegans

Enables diacylglycerol-dependent serine/threonine kinase activity. Involved in several processes, including nervous system process; regulation of presynaptic dense core granule exocytosis; and signaling. Located in cholinergic synapse and neuron projection. Expressed in ganglia; linker cell; and neurons. Human ortholog(s) of this gene implicated in cerebral infarction. Is an ortholog of human PRKCE (protein kinase C epsilon).

pkc-3

Caenorhabditis elegans

Enables protein domain specific binding activity and protein serine/threonine kinase activity. Involved in several processes, including embryo development; gonad development; and response to stress. Located in apical plasma membrane; cortical actin cytoskeleton; and cytosol. Expressed in several structures, including Psub4; enteric muscle; hypodermis; pharyngeal-intestinal valve; and vulva. Human ortholog(s) of this gene implicated in invasive ductal carcinoma and ovarian carcinoma. Is an ortholog of human PRKCI (protein kinase C iota) and PRKCZ (protein kinase C zeta).

pkc-2

Caenorhabditis elegans

Enables calcium,diacylglycerol-dependent serine/threonine kinase activity and protein serine kinase activity. Predicted to be involved in intracellular signal transduction. Located in several cellular components, including cytosol; neuron projection; and neuronal cell body. Expressed in body wall musculature; intestine; neurons; somatic nervous system; and tail ganglion. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; brain disease (multiple); carcinoma (multiple); and ductal carcinoma in situ. Is an ortholog of human PRKCA (protein kinase C alpha) and PRKCB (protein kinase C beta).

eif-1.A

Caenorhabditis elegans

Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytoplasm. Expressed in head and tail. Is an ortholog of human EIF1AX (eukaryotic translation initiation factor 1A X-linked) and EIF1AY (eukaryotic translation initiation factor 1A Y-linked).

her-1

Caenorhabditis elegans

Enables signaling receptor binding activity. Involved in male sex determination. Located in extracellular region.

eas-1

Caenorhabditis elegans

Involved in Golgi vesicle transport. Located in cis-Golgi network. Expressed widely. Is an ortholog of human GOLT1A (golgi transport 1A) and GOLT1B (golgi transport 1B).

arp-1

Caenorhabditis elegans

Part of dynactin complex. Human ortholog(s) of this gene implicated in Down syndrome and colon cancer. Is an ortholog of human ACTR1A (actin related protein 1A).

zchc-1A

Caenorhabditis elegans

Predicted to enable metal ion binding activity. Is an ortholog of human ZC2HC1A (zinc finger C2HC-type containing 1A) and ZC2HC1B (zinc finger C2HC-type containing 1B).

lgl-1

Caenorhabditis elegans

Predicted to enable GTPase activator activity; myosin II binding activity; and syntaxin binding activity. Involved in establishment of spindle orientation and protein localization. Located in basolateral plasma membrane and cell cortex. Expressed in epithelial cell; intestine; spermathecal cell; and vulval cell. Is an ortholog of human LLGL1 (LLGL scribble cell polarity complex component 1) and LLGL2 (LLGL scribble cell polarity complex component 2).