Is affected by several genes including prg-1; hrpk-1; and alg-1 based on RNA-seq studies. Is affected by four chemicals including methylmercury hydroxide; multi-walled carbon nanotube; and nicotine based on RNA-seq studies.
Predicted to enable clathrin adaptor activity. Involved in positive regulation of locomotion. Located in synapse. Expressed in DD neuron; VD neuron; and cholinergic neurons. Is an ortholog of human STON2 (stonin 2).
Enables mRNA binding activity and translation repressor activity. Involved in several processes, including negative regulation of gene expression; nematode male tail tip morphogenesis; and regulation of developmental process. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and ribonucleoprotein granule. Expressed in several structures, including germ cell; hypodermal cell; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in hydrocephalus. Is an ortholog of human TRIM71 (tripartite motif containing 71).
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in body wall musculature; neurons; and somatic nervous system.
Enables store-operated calcium channel activity. Involved in calcium ion transport; intracellular calcium ion homeostasis; and single fertilization. Located in cytoplasmic vesicle and pseudopodium membrane. Expressed in sperm and spermatid.
Predicted to enable metal ion binding activity. Involved in negative regulation of apoptotic process; vacuolar protein processing; and vacuolar transport. Predicted to be located in late endosome. Predicted to be part of HOPS complex. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 29. Is an ortholog of human VPS41 (VPS41 subunit of HOPS complex).
Predicted to enable monoatomic cation transmembrane transporter activity. Predicted to be involved in monoatomic cation transmembrane transport. Predicted to be located in plasma membrane. Is an ortholog of human SLC41A1 (solute carrier family 41 member 1) and SLC41A2 (solute carrier family 41 member 2).
Predicted to be involved in cell projection organization and protein transport. Predicted to be located in centrosome; cilium; and cytoplasm. Human ortholog(s) of this gene implicated in Joubert syndrome 15. Is an ortholog of human CEP41 (centrosomal protein 41).