Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in L-leucine catabolic process and ketone body biosynthetic process. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Is an ortholog of human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase) and HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase like 1).
Enables ubiquitin conjugating enzyme binding activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including determination of adult lifespan; mitophagy; and negative regulation of engulfment of apoptotic cell. Located in mitochondrial outer membrane and neuronal cell body. Part of ubiquitin ligase complex. Expressed in muscle cell and neurons. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Lewy body dementia; Parkinson's disease 2; and female reproductive organ cancer (multiple). Is an ortholog of human PRKN (parkin RBR E3 ubiquitin protein ligase).