Enables ubiquitin conjugating enzyme binding activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including determination of adult lifespan; mitophagy; and negative regulation of engulfment of apoptotic cell. Located in mitochondrial outer membrane and neuronal cell body. Part of ubiquitin ligase complex. Expressed in muscle cell and neurons. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Lewy body dementia; Parkinson's disease 2; and female reproductive organ cancer (multiple). Is an ortholog of human PRKN (parkin RBR E3 ubiquitin protein ligase).
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including ATF6-mediated unfolded protein response; determination of adult lifespan; and endoplasmic reticulum calcium ion homeostasis. Predicted to be located in nucleus. Expressed in several structures, including intestine; muscle cell; pharyngeal gland cell; rectum; and vulva. Human ortholog(s) of this gene implicated in achromatopsia 7. Is an ortholog of human ATF6 (activating transcription factor 6) and ATF6B (activating transcription factor 6 beta).