pdk-1

Caenorhabditis elegans

Enables protein kinase activity. Involved in several processes, including cellular response to reactive oxygen species; dauer larval development; and regulation of synaptic assembly at neuromuscular junction. Located in axon; neuronal cell body; and nucleus. Expressed in several structures, including gonad; intestine; neurons; pharynx; and ventral nerve cord. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and prostate cancer. Is an ortholog of human PDPK1 (3-phosphoinositide dependent protein kinase 1).

spi-1

Caenorhabditis elegans

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region.

akt-2

Caenorhabditis elegans

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and protein serine/threonine kinase activity. Involved in determination of adult lifespan; insulin receptor signaling pathway; and regulation of synaptic assembly at neuromuscular junction. Expressed in several structures, including excretory canal; neurons; pharynx; rectum; and vulva. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); coronary artery disease (multiple); and glucose metabolism disease (multiple). Is an ortholog of human AKT1 (AKT serine/threonine kinase 1); AKT2 (AKT serine/threonine kinase 2); and AKT3 (AKT serine/threonine kinase 3).

dcap-1

Caenorhabditis elegans

Predicted to enable mRNA binding activity. Involved in several processes, including determination of adult lifespan; nematode larval development; and response to stress. Located in P granule and P-body. Expressed in head; motor neurons; neurons; tail; and touch receptor neurons. Is an ortholog of human DCP1A (decapping mRNA 1A) and DCP1B (decapping mRNA 1B).

swm-1

Caenorhabditis elegans

Predicted to enable serine-type endopeptidase inhibitor activity. Involved in spermatid development. Located in extracellular space and secretory vesicle. Expressed in body wall musculature; coelomocyte; reproductive tract; and in male.

sgk-1

Caenorhabditis elegans

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and protein serine/threonine kinase activity. Involved in several processes, including mesendoderm development; positive regulation of vitellogenesis; and regulation of protein localization to basolateral plasma membrane. Located in cytoplasm and nucleus. Expressed in intestine; neurons; and tail neurons. Human ortholog(s) of this gene implicated in cystadenocarcinoma (multiple); granulosa cell tumor; and hypertension. Is an ortholog of human C8orf44-SGK3 (C8orf44-SGK3 readthrough); SGK2 (serum/glucocorticoid regulated kinase 2); and SGK3 (serum/glucocorticoid regulated kinase family member 3).

age-1

Caenorhabditis elegans

Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in several processes, including dauer entry; determination of adult lifespan; and regulation of synaptic assembly at neuromuscular junction. Located in cytoplasm and non-motile cilium. Part of phosphatidylinositol 3-kinase complex. Expressed in amphid neurons; anchor cell; hypodermis; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Is an ortholog of human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta); PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta); and PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma).