Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Expressed in PDE; hypodermal cell; intestine; and pharyngeal muscle cell.
Enriched in ILshVR; PDE socket cell; and ut4 based on single-cell RNA-seq studies. Is affected by daf-16 based on RNA-seq studies. Is affected by four chemicals including rifampin; allantoin; and Sirolimus based on RNA-seq studies.
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in negative regulation of oocyte maturation. Predicted to be located in cytosol; nucleus; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease. Is an ortholog of human PDE8A (phosphodiesterase 8A) and PDE8B (phosphodiesterase 8B).
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; and sleep. Located in synapse. Expressed in DD neuron and VD neuron. Human ortholog(s) of this gene implicated in acrodysostosis and alcohol dependence. Is an ortholog of human PDE4B (phosphodiesterase 4B).
Enables 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of intracellular signal transduction; and response to alkaline pH. Expressed in AFDL; AFDR; and head. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74. Is an ortholog of human PDE1A (phosphodiesterase 1A) and PDE1B (phosphodiesterase 1B).
Enriched in HSNL; ILshVR; and PDE socket cell based on single-cell RNA-seq studies. Is affected by several genes including unc-30; slr-2; and ogt-1 based on RNA-seq and microarray studies. Is affected by Diazinon and Hydrolyzable Tannins based on microarray studies.
Enriched in ILshVR and PDE socket cell based on single-cell RNA-seq studies. Is affected by several genes including rsr-2; kri-1; and hpl-2 based on tiling array; microarray; and RNA-seq studies. Is affected by Tunicamycin and atracurium based on microarray and RNA-seq studies.
Enriched in PDE socket cell and excretory secretory system based on single-cell RNA-seq studies. Is affected by several genes including cua-1; etr-1; and ash-2 based on RNA-seq and microarray studies. Is affected by five chemicals including graphene oxide; stavudine; and tert-Butylhydroperoxide based on RNA-seq studies.
Enriched in I6 neuron; ILshVR; and PDE socket cell based on single-cell RNA-seq studies. Is affected by several genes including cyc-1; mter-4; and etr-1 based on microarray and RNA-seq studies. Is affected by seven chemicals including metformin; Psoralens; and allantoin based on RNA-seq and microarray studies.