Enables voltage-gated calcium channel activity. Involved in several processes, including determination of left/right asymmetry in nervous system; positive regulation of striated muscle contraction; and regulation of nematode pharyngeal pumping. Located in plasma membrane. Expressed in several structures, including alimentary muscle; neurons; preanal ganglion; tail; and vulval muscle. Used to study Duchenne muscular dystrophy and Timothy syndrome. Human ortholog(s) of this gene implicated in several diseases, including Brugada syndrome 3; X-linked recessive disease (multiple); and muscle tissue disease (multiple). Is an ortholog of human CACNA1C (calcium voltage-gated channel subunit alpha1 C); CACNA1F (calcium voltage-gated channel subunit alpha1 F); and CACNA1S (calcium voltage-gated channel subunit alpha1 S).
Involved in embryonic morphogenesis and hemidesmosome assembly. Located in hemidesmosome. Expressed in head neurons; mechanosensory neurons; rectum; seam cell; and spermatheca.
Enables integrin binding activity and protein-macromolecule adaptor activity. Involved in several processes, including integrin-mediated signaling pathway; muscle cell cellular homeostasis; and positive regulation of supramolecular fiber organization. Located in adherens junction; basal plasma membrane; and contractile muscle fiber. Part of integrin complex. Expressed in body wall musculature; gonad; non-striated muscle; pharynx; and touch receptor neurons. Human ortholog(s) of this gene implicated in ovarian cancer; pancreatic cancer; and prostate adenocarcinoma. Is an ortholog of human ILK (integrin linked kinase).
Enables integrin binding activity and protein-macromolecule adaptor activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of supramolecular fiber organization; and regulation of engulfment of apoptotic cell. Located in cell-substrate junction; contractile muscle fiber; and plasma membrane. Expressed in body wall musculature; non-striated muscle; and spermatheca. Used to study Kindler syndrome. Human ortholog(s) of this gene implicated in several diseases, including Kindler syndrome; leukocyte adhesion deficiency (multiple); and telangiectasis. Is an ortholog of human FERMT1 (FERM domain containing kindlin 1) and FERMT2 (FERM domain containing kindlin 2).
Enables troponin I binding activity. Involved in embryo development; muscle contraction; and skeletal muscle thin filament assembly. Located in contractile muscle fiber. Expressed in body wall musculature; gonadal sheath cell; rectal muscle; and vulval muscle. Is an ortholog of human CALML6 (calmodulin like 6).
Predicted to enable integrin binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of cellular component organization; and regulation of locomotion. Located in several cellular components, including contractile muscle fiber; focal adhesion; and lateral plasma membrane. Part of integrin complex. Expressed in several structures, including GABAergic neurons; egg-laying apparatus; enteric muscle; gonad; and vulval precursor cell. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); and lung carcinoma (multiple). Is an ortholog of human ITGB1 (integrin subunit beta 1).
Enables transmembrane signaling receptor activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of cellular component organization; and regulation of locomotion. Located in M band; cell surface; and striated muscle dense body. Expressed in body wall musculature; distal tip cell; hypodermis; and touch receptor neurons. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; blood platelet disease (multiple); and von Willebrand's disease (multiple). Is an ortholog of several human genes including ITGA2B (integrin subunit alpha 2b); ITGA5 (integrin subunit alpha 5); and ITGAV (integrin subunit alpha V).
Predicted to enable inositol-polyphosphate 5-phosphatase activity. Expressed in pharyngeal muscle cell and rectal epithelium. Is an ortholog of human INPP5A (inositol polyphosphate-5-phosphatase A).