pat-12

Caenorhabditis elegans

Involved in embryonic morphogenesis and hemidesmosome assembly. Located in hemidesmosome. Expressed in head neurons; mechanosensory neurons; rectum; seam cell; and spermatheca.

pat-4

Caenorhabditis elegans

Enables integrin binding activity and protein-macromolecule adaptor activity. Involved in several processes, including integrin-mediated signaling pathway; muscle cell cellular homeostasis; and positive regulation of supramolecular fiber organization. Located in adherens junction; basal plasma membrane; and contractile muscle fiber. Part of integrin complex. Expressed in body wall musculature; gonad; non-striated muscle; pharynx; and touch receptor neurons. Human ortholog(s) of this gene implicated in ovarian cancer; pancreatic cancer; and prostate adenocarcinoma. Is an ortholog of human ILK (integrin linked kinase).

unc-112

Caenorhabditis elegans

Enables integrin binding activity and protein-macromolecule adaptor activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of supramolecular fiber organization; and regulation of engulfment of apoptotic cell. Located in cell-substrate junction; contractile muscle fiber; and plasma membrane. Expressed in body wall musculature; non-striated muscle; and spermatheca. Used to study Kindler syndrome. Human ortholog(s) of this gene implicated in several diseases, including Kindler syndrome; leukocyte adhesion deficiency (multiple); and telangiectasis. Is an ortholog of human FERMT1 (FERM domain containing kindlin 1) and FERMT2 (FERM domain containing kindlin 2).

pat-10

Caenorhabditis elegans

Enables troponin I binding activity. Involved in embryo development; muscle contraction; and skeletal muscle thin filament assembly. Located in contractile muscle fiber. Expressed in body wall musculature; gonadal sheath cell; rectal muscle; and vulval muscle. Is an ortholog of human CALML6 (calmodulin like 6).

pat-3

Caenorhabditis elegans

Predicted to enable integrin binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of cellular component organization; and regulation of locomotion. Located in several cellular components, including contractile muscle fiber; focal adhesion; and lateral plasma membrane. Part of integrin complex. Expressed in several structures, including GABAergic neurons; egg-laying apparatus; enteric muscle; gonad; and vulval precursor cell. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); and lung carcinoma (multiple). Is an ortholog of human ITGB1 (integrin subunit beta 1).

pat-2

Caenorhabditis elegans

Enables transmembrane signaling receptor activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of cellular component organization; and regulation of locomotion. Located in M band; cell surface; and striated muscle dense body. Expressed in body wall musculature; distal tip cell; hypodermis; and touch receptor neurons. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; blood platelet disease (multiple); and von Willebrand's disease (multiple). Is an ortholog of several human genes including ITGA2B (integrin subunit alpha 2b); ITGA5 (integrin subunit alpha 5); and ITGAV (integrin subunit alpha V).

unc-97

Caenorhabditis elegans

Enables myosin binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of sarcomere organization; and sensory perception of mechanical stimulus. Located in several cellular components, including adherens junction; basal plasma membrane; and contractile muscle fiber. Expressed in body wall musculature and vulval muscle. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2W. Is an ortholog of human LIMS1 (LIM zinc finger domain containing 1) and LIMS2 (LIM zinc finger domain containing 2).

pat-6

Caenorhabditis elegans

Predicted to enable actin binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of sarcomere organization; and striated muscle cell development. Located in M band; basal plasma membrane; and striated muscle dense body. Expressed in body wall musculature; gonad; non-striated muscle; and touch receptor neurons. Is an ortholog of human PARVA (parvin alpha).

rnf-121

Caenorhabditis elegans

Enables ubiquitin protein ligase activity. Involved in ERAD pathway; PERK-mediated unfolded protein response; and inductive cell migration. Located in Golgi membrane and sarcoplasmic reticulum membrane. Expressed in body wall musculature; gonad; hypodermis; and vulva. Is an ortholog of human RNF121 (ring finger protein 121) and RNF175 (ring finger protein 175).

ina-1

Caenorhabditis elegans

Enables transmembrane signaling receptor activity. Involved in several processes, including anatomical structure morphogenesis; cell-cell adhesion mediated by integrin; and generation of neurons. Located in phagocytic cup. Part of integrin complex. Expressed in several structures, including distal tip cell; hermaphrodite gonad; neurons; ventral nerve cord; and vulE. Used to study cancer and epilepsy. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; congenital muscular dystrophy due to integrin alpha-7 deficiency; and junctional epidermolysis bullosa with pyloric atresia. Is an ortholog of human ITGA6 (integrin subunit alpha 6).