pash-1

Caenorhabditis elegans

Predicted to enable double-stranded RNA binding activity and primary miRNA binding activity. Involved in primary miRNA processing and regulation of developmental process. Predicted to be part of microprocessor complex. Expressed in head; hypodermis; intestine; marginal cell; and pharyngeal muscle cell. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in alcohol dependence. Is an ortholog of human DGCR8 (DGCR8 microprocessor complex subunit).

drsh-1

Caenorhabditis elegans

Enables ribonuclease III activity. Involved in primary miRNA processing and sexual reproduction. Predicted to be located in nucleus. Predicted to be part of microprocessor complex. Is an ortholog of human DROSHA (drosha ribonuclease III).