Enables several functions, including NAD+ nucleosidase activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including NAD catabolic process; defense response to other organism; and regulation of gene expression. Acts upstream of or within serotonin biosynthetic process. Located in axon cytoplasm and cell body. Expressed in head. Used to study amyotrophic lateral sclerosis. Is an ortholog of human SARM1 (sterile alpha and TIR motif containing 1).
Enables calcium channel inhibitor activity and protein kinase inhibitor activity. Involved in determination of left/right asymmetry in nervous system. Located in plasma membrane and plasma membrane bounded cell projection. Expressed in anterior hypodermis; blast cell; excretory cell; neurons; and tail hypodermis.
Enables sequence-specific DNA binding activity. Involved in determination of left/right asymmetry in nervous system and negative regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in amphid sheath cell; intestine; and neurons.
Enables MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including determination of adult lifespan; positive regulation of macromolecule biosynthetic process; and response to stress. Located in axon cytoplasm; neuronal cell body; and postsynaptic density. Expressed in head; rectal gland cell; and tail. Used to study amphetamine abuse. Human ortholog(s) of this gene implicated in Huntington's disease and perinatal necrotizing enterocolitis. Is an ortholog of human MAP3K5 (mitogen-activated protein kinase kinase kinase 5).