nos-2

Caenorhabditis elegans

Predicted to enable mRNA binding activity and zinc ion binding activity. Involved in oogenesis and regulation of cell cycle. Located in cytoplasm. Expressed in P0; P4; Z2; and Z3. Human ortholog(s) of this gene implicated in spermatogenic failure 12. Is an ortholog of human NANOS1 (nanos C2HC-type zinc finger 1); NANOS2 (nanos C2HC-type zinc finger 2); and NANOS3 (nanos C2HC-type zinc finger 3).

nos-1

Caenorhabditis elegans

Predicted to enable mRNA binding activity. Involved in medium-term memory and short-term memory. Predicted to be located in perinuclear region of cytoplasm. Expressed in Z2 and Z3. Human ortholog(s) of this gene implicated in spermatogenic failure 12. Is an ortholog of human NANOS1 (nanos C2HC-type zinc finger 1); NANOS2 (nanos C2HC-type zinc finger 2); and NANOS3 (nanos C2HC-type zinc finger 3).

nos-3

Caenorhabditis elegans

Predicted to enable RNA binding activity. Involved in positive regulation of meiotic nuclear division. Located in cytoplasm. Expressed in several structures, including Psub3; Psub4; Z2; Z3; and germ line.

puf-7

Caenorhabditis elegans

Predicted to enable mRNA 3'-UTR binding activity. Involved in germ cell development. Predicted to be located in cytoplasm and nucleus.

fbf-2

Caenorhabditis elegans

Enables mRNA 3'-UTR binding activity. Involved in negative regulation of translation. Located in P granule. Used to study obesity.

gld-1

Caenorhabditis elegans

Enables mRNA 3'-UTR binding activity; mRNA 5'-UTR binding activity; and single-stranded RNA binding activity. Involved in several processes, including oocyte fate determination; positive regulation of reproductive process; and regulation of gene expression. Located in P granule and cytosol. Expressed in body wall musculature; germ line; neurons; ventral nerve cord; and in male. Is an ortholog of human QKI (QKI, KH domain containing RNA binding).

snr-6

Caenorhabditis elegans

Predicted to enable RNA binding activity. Predicted to be involved in spliceosomal snRNP assembly. Located in P granule. Expressed in gonad. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hypotrichosis (multiple); and lupus nephritis. Is an ortholog of human SNRPE (small nuclear ribonucleoprotein polypeptide E).

fbf-1

Caenorhabditis elegans

Enables mRNA 3'-UTR binding activity. Involved in several processes, including germline cell cycle switching, mitotic to meiotic cell cycle; olfactory learning; and regulation of gene expression. Located in germ cell nucleus and perinuclear region of cytoplasm. Expressed in germ line.

gld-3

Caenorhabditis elegans

Enables polynucleotide adenylyltransferase activator activity and protein domain specific binding activity. Involved in several processes, including cytosolic mRNA polyadenylation; developmental process involved in reproduction; and positive regulation of meiotic nuclear division. Located in P granule. Part of RNA-directed RNA polymerase complex. Expressed in germ line and in male.

spat-3

Caenorhabditis elegans

Enables histone ubiquitin ligase activity. Involved in several processes, including negative regulation of gene expression, epigenetic; negative regulation of vulval development; and nematode male tail tip morphogenesis. Predicted to be part of PcG protein complex and ubiquitin ligase complex. Expressed in several structures, including AIYL; AIYR; SMDDL; and SMDDR. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in Luo-Schoch-Yamamoto syndrome and pancreatic ductal carcinoma. Is an ortholog of human RING1 (ring finger protein 1) and RNF2 (ring finger protein 2).