ncl-1

Caenorhabditis elegans

Enables translation repressor activity. Involved in several processes, including negative regulation of DNA-templated transcription; negative regulation of ribosome biogenesis; and nucleologenesis. Located in cytoplasm. Expressed in head and tail. Is an ortholog of human TRIM3 (tripartite motif containing 3).

spi-1

Caenorhabditis elegans

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region.

nhl-1

Caenorhabditis elegans

Enables ubiquitin-protein transferase activity. Involved in protein ubiquitination. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2R. Is an ortholog of human TRIM2 (tripartite motif containing 2).

dcap-1

Caenorhabditis elegans

Predicted to enable mRNA binding activity. Involved in several processes, including determination of adult lifespan; nematode larval development; and response to stress. Located in P granule and P-body. Expressed in head; motor neurons; neurons; tail; and touch receptor neurons. Is an ortholog of human DCP1A (decapping mRNA 1A) and DCP1B (decapping mRNA 1B).

nhl-2

Caenorhabditis elegans

Enables DEAD/H-box RNA helicase binding activity. Involved in positive regulation of development, heterochronic; protein localization to cell cortex; and regulation of establishment of cell polarity. Located in P granule and P-body. Expressed in several structures, including germ line. Is an ortholog of human TRIM45 (tripartite motif containing 45).

swm-1

Caenorhabditis elegans

Predicted to enable serine-type endopeptidase inhibitor activity. Involved in spermatid development. Located in extracellular space and secretory vesicle. Expressed in body wall musculature; coelomocyte; reproductive tract; and in male.

lin-41

Caenorhabditis elegans

Enables mRNA binding activity and translation repressor activity. Involved in several processes, including negative regulation of gene expression; nematode male tail tip morphogenesis; and regulation of developmental process. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and ribonucleoprotein granule. Expressed in several structures, including germ cell; hypodermal cell; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in hydrocephalus. Is an ortholog of human TRIM71 (tripartite motif containing 71).