hmit-1.1

Caenorhabditis elegans

Predicted to enable myo-inositol:proton symporter activity. Predicted to be involved in myo-inositol transport and transmembrane transport. Located in apical plasma membrane. Expressed in intestinal cell. Is an ortholog of human SLC2A13 (solute carrier family 2 member 13).

hmit-1.3

Caenorhabditis elegans

Predicted to enable myo-inositol:proton symporter activity. Predicted to be involved in myo-inositol transport and transmembrane transport. Located in apical plasma membrane. Expressed in amphid sheath cell; head; and phasmid sheath cell. Is an ortholog of human SLC2A13 (solute carrier family 2 member 13).

hmit-1.2

Caenorhabditis elegans

Predicted to enable myo-inositol:proton symporter activity. Predicted to be involved in myo-inositol transport and transmembrane transport. Located in apical plasma membrane and basal plasma membrane. Expressed in amphid sheath cell; excretory canal; and phasmid sheath cell. Is an ortholog of human SLC2A13 (solute carrier family 2 member 13).

sir-2.3

Caenorhabditis elegans

Predicted to enable histone deacetylase activity. Predicted to be involved in epigenetic regulation of gene expression. Located in mitochondrion. Expressed in body wall musculature; head; pharynx; and somatic gonad. Is an ortholog of human SIRT4 (sirtuin 4).

C54E4.5

Caenorhabditis elegans

Predicted to enable inositol oxygenase activity. Predicted to be involved in inositol catabolic process. Predicted to be located in cytoplasm. Is an ortholog of human MIOX (myo-inositol oxygenase).

polk-1

Caenorhabditis elegans

Predicted to enable DNA-directed DNA polymerase activity. Involved in embryo development and error-prone translesion synthesis. Predicted to be located in nucleus. Is an ortholog of human POLK (DNA polymerase kappa).

myo-2

Caenorhabditis elegans

Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in muscle contraction and sarcomere organization. Predicted to be located in cytoplasm and myosin filament. Predicted to be part of muscle myosin complex. Expressed in neurons and pharynx. Human ortholog(s) of this gene implicated in several diseases, including congenital heart disease (multiple); distal myopathy 1; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including MYH1 (myosin heavy chain 1); MYH2 (myosin heavy chain 2); and MYH3 (myosin heavy chain 3).

zip-1

Caenorhabditis elegans

Predicted to enable DNA binding activity.

polh-1

Caenorhabditis elegans

Predicted to enable DNA-directed DNA polymerase activity. Involved in embryo development; error-prone translesion synthesis; and negative regulation of mitotic DNA damage checkpoint. Located in nucleus. Human ortholog(s) of this gene implicated in female breast cancer and xeroderma pigmentosum variant type. Is an ortholog of human POLH (DNA polymerase eta).

arf-6

Caenorhabditis elegans

Predicted to enable GTP binding activity and GTPase activity. Involved in negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; and positive regulation of endosome to plasma membrane protein transport. Located in basolateral plasma membrane; cytoplasmic side of apical plasma membrane; and recycling endosome membrane. Expressed in several structures, including excretory cell; intestine; pharyngeal muscle cell; ventral nerve cord; and vulva. Is an ortholog of human ARF6 (ADP ribosylation factor 6).