mua-6

Caenorhabditis elegans

Predicted to be a structural constituent of cytoskeleton. Involved in cell-cell adhesion. Located in hemidesmosome. Expressed in hypodermis; touch receptor neurons; uterus; and ventral cord neurons. Human ortholog(s) of this gene implicated in partial lipodystrophy; primary autosomal recessive microcephaly; and progressive myoclonus epilepsy 9. Is an ortholog of human LMNB2 (lamin B2).

vps-15

Caenorhabditis elegans

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in autophagy and vacuolar transport. Predicted to be located in late endosome and nucleus-vacuole junction. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Is an ortholog of human PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4).

rpac-40

Caenorhabditis elegans

Predicted to enable DNA-directed 5'-3' RNA polymerase activity and protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase I and transcription by RNA polymerase III. Predicted to be part of RNA polymerase I complex and RNA polymerase III complex. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 3 and hypomyelinating leukodystrophy 11. Is an ortholog of human POLR1C (RNA polymerase I and III subunit C).

rpc-11

Caenorhabditis elegans

Predicted to enable DNA-directed 5'-3' RNA polymerase activity; nucleic acid binding activity; and zinc ion binding activity. Predicted to contribute to RNA polymerase III activity. Predicted to be involved in termination of RNA polymerase III transcription. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 21. Is an ortholog of human POLR3K (RNA polymerase III subunit K).

rpc-2

Caenorhabditis elegans

Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and ribonucleoside binding activity. Predicted to contribute to RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase III. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease and hypomyelinating leukodystrophy 8. Is an ortholog of human POLR3B (RNA polymerase III subunit B).

rpc-1

Caenorhabditis elegans

Predicted to enable DNA binding activity and DNA-directed 5'-3' RNA polymerase activity. Predicted to contribute to RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase III. Predicted to be located in nuclear lumen and protein-containing complex. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in Wiedemann-Rautenstrauch syndrome and hypomyelinating leukodystrophy 7. Is an ortholog of human POLR3A (RNA polymerase III subunit A).

Y47G6A.9

Caenorhabditis elegans

Predicted to be involved in transcription by RNA polymerase III. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Is an ortholog of human POLR3G (RNA polymerase III subunit G) and POLR3GL (RNA polymerase III subunit GL).

rpb-12

Caenorhabditis elegans

Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and zinc ion binding activity. Predicted to contribute to RNA polymerase I activity; RNA polymerase II activity; and RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase I; transcription by RNA polymerase II; and transcription by RNA polymerase III. Predicted to be part of RNA polymerase I complex; RNA polymerase II, core complex; and RNA polymerase III complex. Is an ortholog of human POLR2K (RNA polymerase II, I and III subunit K).

rpb-8

Caenorhabditis elegans

Predicted to enable DNA binding activity and DNA-directed 5'-3' RNA polymerase activity. Predicted to contribute to RNA polymerase I activity; RNA polymerase II activity; and RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase I; transcription by RNA polymerase II; and transcription by RNA polymerase III. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex; RNA polymerase II, core complex; and RNA polymerase III complex. Is an ortholog of human POLR2H (RNA polymerase II, I and III subunit H).

tftc-3

Caenorhabditis elegans

Predicted to be involved in transcription by RNA polymerase III. Predicted to be part of transcription factor TFIIIC complex. Is an ortholog of human GTF3C3 (general transcription factor IIIC subunit 3).